Patent

1. A compound of formula (I)

wherein

X is a radioactive isotope selected from the group consisting of 18 F, 76 Br, 123 I, 124 I, 125 I, and 131 I;

Y is —NR—C(═O)— or —C(═O)—NR—;

m is an integer selected from the group consisting of 1, 2, 3, and 4;

n is an integer selected from the group consisting of 1, 2, 3, 4, and 5;

p is an integer selected from the group consisting of 1, 2, and 3;

R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted alkylaryl substituted or unsubstituted arylalkyl, substituted or unsubstituted alkylheteroaryl, substituted or unsubstituted heteroalkylaryl, and substituted or unsubstituted naphthyl, substituted or unsubstituted biphenyl;

each R 1 can independently be the same or different and is selected from the group consisting of hydrogen, halogen, alkoxyl, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted naphthyl, and substituted or unsubstituted biphenyl; and stereoisomers or pharmaceutically acceptable salts thereof.

2. The compound of claim 1 , wherein the compound of formula (I) is a compound of formula (II):

3. The compound of claim 1 , wherein the radioactive isotope 18 F.

4. The compound of claim 1 , wherein the compound of formula (I) is

5. A method for imaging soluble epoxide hydrolase (sEH), the method comprising administering and/or contacting sEH with an effective amount of a compound of formula (I), and making an image, the compound of formula (I) comprising:

wherein:

X is selected from the group consisting of 18 F, 76 Br, 123 I, 124 I, 125 I, and 131 I;

Y is —NR—C(═O)— or —C(═O)—NR—;

m is an integer selected from the group consisting of 1, 2, 3, and 4;

n is an integer selected from the group consisting of 1, 2, 3, 4, and 5;

p is an integer selected from the group consisting of 1, 2, and 3;

R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted alkylaryl substituted or unsubstituted arylalkyl, substituted or unsubstituted alkylheteroaryl, substituted or unsubstituted heteroalkylaryl, and substituted or unsubstituted naphthyl, substituted or unsubstituted biphenyl;

each R 1 can independently be the same or different and is selected from the group consisting of hydrogen, halogen, alkoxyl, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted naphthyl, and substituted or unsubstituted biphenyl;

and stereoisomers or pharmaceutically acceptable salts thereof.

6. The method of claim 5 , wherein the compound of formula (I) is a compound of formula (II):

7. The method of claim 5 , wherein X is 18 F.

8. The method of claim 5 , wherein the compound of formula (I) is:

9. The method of claim 5 , wherein the image is obtained by using positron emission tomography.

10. The method of claim 5 , wherein the compound of formula (I) is highly specific to sEH.

11. The method of claim 10 , wherein the specificity is up to about 95%.

12. The method of claim 5 , wherein sEH is in vitro, in vivo, or ex vivo.

13. The method of claim 5 , wherein sEH is present in a subject.

14. The method of claim 13 , when the subject is human.

15. The method of claim 13 , wherein the compound of formula (I) is able to cross the blood-brain-barrier and wherein sEH is present in the brain of the subject.

16. The method of claim 13 , wherein the method is non-invasive.

17. The method of claim 13 , wherein the compound of formula (I) readily enters the brain of the subject.

18. The method of claim 13 , wherein the compound of formula (I) is cleared from the brain of the subject.

19. A method for inhibiting soluble epoxide hydrolase (sEH) in the treatment of a sEH-mediated disease, the method comprising administering to a subject a therapeutically effective amount of a compound of formula (I), thereby inhibiting sEH.

20. The method of claim 19 , wherein the soluble epoxide hydrolase mediated disease is selected from the group consisting of hypertension, atherosclerosis, inflammation, diabetes related diseases, pain, pulmonary diseases, Alzheimer's disease, vascular cognitive impairment (VCI), and stroke.

21. A pharmaceutical composition comprising a compound according to claim 1 , and a pharmaceutically acceptable carrier, diluent, or excipient.

22. A kit comprising a packaged pharmaceutical composition comprising a compound according to claim 1 .