Nitric oxide topical application apparatus and methods
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.
1. A composition for transdermal absorption of nitric oxide comprising:
a first solution comprising water, at least one nitrite reactant, and a cationic surfactant;
a second solution comprising water, at least one acidic reactant, and the cationic surfactant;
a first foam obtained by aerating the first solution;
a second foam obtained by aerating the second solution; and
a collapsible foam obtained by mixing the first foam and the second foam.
2. The composition of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 1 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 6 g of citric acid, and 3 g of the cationic surfactant.
3. The composition of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 1 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 8 g of citric acid, and 3 g of the cationic surfactant.
4. The composition of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 2 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 10 g of citric acid, and 6 g of the cationic surfactant.
5. The composition of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 2 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of ascorbic acid, 8 g of citric acid, and 6 g of the cationic surfactant.
6. The composition of claim 2 , wherein the collapsible foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 90% and 120%.
7. The composition of claim 5 , wherein the collapsible foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70%.
8. The composition of claim 1 , wherein the nitrite reactant is selected from the group consisting of sodium nitrite and potassium nitrite, and the acidic reactant is selected from the group consisting of citric acid, lactic acid, salicylic acid, and phosphoric acid.
9. A composition for treating skin comprising:
a first solution comprising approximately 100 mL of water, 10 g of sodium nitrite, and 2 g of a cationic surfactant; and
a second solution comprising approximately 100 mL of water, 10 g of citric acid, and 6 g of the cationic surfactant;
a first foam obtained by aerating the first solution;
a second foam obtained by aerating the second solution; and
a collapsible foam obtained by mixing the first foam and the second foam.
10. The composition of claim 9 , wherein the first solution further comprises 2 g of sodium bicarbonate.
11. The composition of claim 9 , wherein the collapsible foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 90% and 120%.
12. The composition of claim 10 , wherein the collapsible foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70%.
13. The composition of claim 9 , wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.
14. A collapsible foam composition for transdermal absorption of nitric oxide comprising:
a first solution comprising water, at least one nitrite reactant, and a cationic surfactant;
a second solution comprising water, at least one acidic reactant, and the cationic surfactant;
a first foam obtained by aerating the first solution;
a second foam obtained by aerating the second solution; and
the collapsible foam obtained by mixing the first foam and the second foam, wherein the collapsible foam substantially collapses within approximately five (5) minutes after being placed on a portion of skin of a user.
15. The collapsible foam composition of claim 14 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 1 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 8 g of citric acid, and 3 g of the cationic surfactant.
16. The collapsible foam composition of claim 14 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 2 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 10 g of citric acid, and 6 g of the cationic surfactant.
17. The collapsible foam composition of claim 14 , wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.
18. The collapsible foam composition of claim 14 , wherein the nitrite reactant is selected from the group consisting of sodium nitrite and potassium nitrite, and the acidic reactant is selected from the group consisting of citric acid, lactic acid, salicylic acid, phosphoric acid, and ascorbic acid.
19. The collapsible foam composition of claim 14 , wherein the collapsible foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 90% and 120%.
20. The collapsible foam composition of claim 15 , wherein the collapsible foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70%.