Bisamide derivative of dicarboxylic acid as an agent for stimulating tissue regeneration and recovery of diminished tissue function
The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ function. A medicinal agent for the treatment and/or prophylaxis of a pathological condition selected from the group including metabolic syndrome, impaired glucose tolerance, hepatitis, particularly chronic hepatitis and toxic hepatitis, idiopathic pulmonary fibrosis (IPF), emphysema of the lungs, chronic obstructive pulmonary disease (COPD) and cachexia, particularly as a result of impaired glucose tolerance, pulmonary fibrosis, chronic obstructive pulmonary disease, cancer and other diseases, is proposed in the form of an agent based on Treamide. The latter is a bisamide derivative of dicarboxylic acid of formula (I) or a pharmaceutically acceptable salt thereof.
1. A method for treating structural or functional damage of a tissue selected from the group consisting of a pancreatic tissue, a liver tissue, a lung tissue, a muscular tissue, a spermatogenic tissue, a testicular tissue, and a prostate tissue, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein a pathological condition is associated with the structural or functional damage, said pathological condition selected from the group consisting of metabolic syndrome, glucose tolerance failure, hepatitis, idiopathic pulmonary fibrosis, pulmonary emphysema, chronic obstructive pulmonary disease, cachexia, hypogonadism, prostatitis, benign prostatic hyperplasia, correlative testicular failure, and autoimmune orchitis.
3. The method of claim 2 , wherein the prostatitis is chronic prostatitis, in particular abacterial chronic prostatitis; or category 3B prostatitis, or autoimmune prostatitis.
4. A method for recovery of liver structure and function in the treatment and/or prevention of a pathological condition, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
5. The method of claim 4 , wherein the pathological condition is hepatitis, in particular chronic hepatitis and toxic hepatitis.
6. A method for recovery of lung structure and function in the treatment and/or prevention of a pathological condition, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
7. The method of claim 6 , wherein the pathological condition is selected from the group consisting of chronic obstructive pulmonary disease (COPD), pulmonary emphysema, and idiopathic pulmonary fibrosis.
8. A method for recovery of pancreas structure and function in the treatment and/or prevention of a pathological condition, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.