Expandable pill
An ingestible pill is provided that includes an enteric coating and a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and (b) needles. The patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least 50% of the needles are coupled to the patch along the inner crease sides. The patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter. Other embodiments are also described.
1. An ingestible pill comprising:
an enteric coating; and
a medication-delivery device, which comprises (a) a patch having upper and lower surfaces that face in generally opposite directions; and (b) needles, wherein the patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least one of the needles is coupled to the patch along the inner crease sides, and
wherein the patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter.
2. The ingestible pill according to claim 1 , wherein the patch can inscribe a circle having a diameter of between 2 and 10 cm when the patch assumes the expanded shape and is unconstrained.
3. The ingestible pill according to claim 1 , wherein each of the needles has a length of between 20 and 300 microns.
4. The ingestible pill according to claim 1 , wherein the patch is configured such that the expanded shape is generally flat when the medication-delivery device is unconstrained.
5. The ingestible pill according to claim 1 , wherein between 0% and 10% of the needles are coupled to the patch along the outer crease sides when the patch is disposed within the enteric coating.
6. The ingestible pill according to claim 1 , wherein the ingestible pill is configured such that when the patch assumes the expanded shape upon dissolving of the enteric coating in a small intestine of a subject, the upper surface of the patch contacts an intestinal wall, thereby bringing the needles into contact with the intestinal wall.
7. The ingestible pill according to claim 6 , wherein at least 50% of the needles are coupled to the upper surface of the patch along the inner crease sides when the patch is disposed within the enteric coating.
8. The ingestible pill according to claim 7 , wherein at least 80% of the needles are coupled to the upper surface of the patch when the patch is disposed within the enteric coating.
9. The ingestible pill according to claim 6 , wherein the patch is disposed within the enteric coating, folded such that when the patch assumes the expanded shape upon dissolving of the enteric coating in the small intestine, the upper face of the patch contacts the intestinal wall, thereby bringing the needles into contact with the intestinal wall.
10. The ingestible pill according to claim 1 , wherein the medication-delivery device further comprises a medication, and wherein the needles are configured to deliver the medication.
11. The ingestible pill according to claim 10 , wherein the needles are hollow and are configured to deliver the medication.
12. The ingestible pill according to claim 1 , wherein the needles comprise a solid medication.
13. The ingestible pill according to claim 1 , wherein the patch is disposed within the enteric coating, folded so as to define a plurality of creases.
14. The ingestible pill according to claim 13 , wherein the patch is disposed within the enteric coating, folded first in half and then accordion-folded.
15. The ingestible pill according to claim 13 , wherein the needles are not coupled to respective inner crease sides of a portion of the creases.
16. A method comprising:
receiving, by a subject, an ingestible pill, which includes (i) an enteric coating and (ii) a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and needles, wherein the patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least one of the needles is coupled to the patch along the inner crease sides; and
swallowing the ingestible pill by the subject, so that the coating dissolves in the small intestine and the patch assumes an expanded shape, in which the patch has an outer perimeter.
17. The method according to claim 16 , wherein between 0% and 10% of the needles are coupled to the patch along the outer crease sides when the patch is disposed within the enteric coating.
18. The method according to claim 16 , wherein the ingestible pill is configured such that when the patch assumes the expanded shape upon dissolving of the enteric coating in a small intestine of a subject, the upper surface of the patch contacts an intestinal wall, thereby bringing the needles into contact with the intestinal wall, and wherein at least 50% of the needles are coupled to the upper surface of the patch along the inner crease sides when the patch is disposed within the enteric coating.
19. The method according to claim 16 , wherein the medication-delivery device further comprises a medication, and wherein the needles are configured to deliver the medication.
20. The method according to claim 16 , wherein the needles comprise a solid medication.
21. The method according to claim 16 , wherein the patch is disposed within the enteric coating, folded so as to define a plurality of creases, and wherein the needles are not coupled to respective inner crease sides of a portion of the creases.