Compositions and methods for the treatment of presbyopia
The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine. The compositions optionally contain a surfactant and a viscosity agent.
1. An ophthalmological composition for the treatment of presbyopia comprising from 0.225% to 1.85% w/v aceclidine as the only ophthalmologically active agent and one or more nonionic surfactants, wherein w/v denotes weight by total volume of the composition.
2. The composition of claim 1 , further comprising sodium chloride.
3. An ophthalmological composition for the treatment of presbyopia comprising from 0.225% to 1.85% w/v aceclidine as the only active agent, and a viscosity agent, wherein w/v denotes weight by total volume of the composition.
4. The composition of claim 3 , further comprising one or more nonionic surfactants at a total concentration from about 2% to about 7% w/v.
5. The composition of claim 4 , wherein the one or more nonionic surfactants are selected from the group consisting of a polysorbate, tyloxapol, a poloxamer, a cyclodextrin, d-α-tocopheryl polyethylene glycol 1000 succinate, a polyoxyl castor oil, a polyoxyl stearate, polyethylene glycol, a polyoxyethylene glycol alkyl ether and 2-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethanol.
6. The composition of claim 4 , wherein the one or more nonionic surfactants is a polysorbate.
7. The composition of claim 4 , wherein the one or more nonionic surfactants is polysorbate 80.
8. The composition of claim 3 , wherein the viscosity agent provides a viscosity of the total composition of about 25 centipoise or more at 25° C. and 0 shear.
9. The composition of claim 3 , wherein the viscosity agent provides a viscosity of the total composition from about 50 to about 10,000 centipoise or more at 25° C. and 0 shear.
10. The composition of claim 3 , wherein the viscosity agent provides a viscosity of the total composition from about 100 to about 5,000 centipoise or more at 25° C. and 0 shear.
11. The composition of claim 3 , wherein the viscosity agent provides a viscosity of the total composition from about 150 to about 450 centipoise or more at 25° C. and 0 shear.
12. The composition of claim 3 , wherein the viscosity agent is selected from the group consisting of a cellulose derivative, hyaluronate, a carbomer and a gum.
13. The composition of claim 3 , wherein the viscosity agent is selected from the group consisting of high molecular weight carboxymethyl cellulose, carbomer 940 and hydroxypropylmethyl cellulose.
14. The composition of claim 1 , wherein the composition is stable at temperatures from about 2 to about 8° C.
15. The composition of claim 3 , wherein the composition is stable at temperatures from about 2 to about 8° C.