Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
1. A method of increasing dextromethorphan plasma levels in a human being, comprising orally administering, twice a day, a dosage form comprising bupropion and dextromethorphan to the human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the dosage form contains about 100 mg to about 200 mg of the bupropion and about 40 mg to about 60 mg of the dextromethorphan, wherein the dosage form is orally administered twice a day for at least eight consecutive days, and wherein on the eighth day that the dosage form is orally administered twice a day, the human being has a C max of dextromethorphan that is at least about 15 times the C max that would be achieved by orally administering the same amount of the dextromethorphan without the bupropion twice a day for eight consecutive days.
2. The method of claim 1 , wherein the dosage form contains about 42 mg to about 48 mg of the dextromethorphan and about 100 mg to about 140 mg of the bupropion.
3. The method of claim 1 , wherein on the eighth day that the dosage form is orally administered twice a day, the human being has a C max of dextromethorphan that is at least about 20 times the C max that would be achieved by orally administering the same amount of the dextromethorphan without the bupropion twice a day for eight consecutive days.
4. The method of claim 1 , wherein on the eighth day that the dosage form is orally administered twice a day, the human being has a C min of dextromethorphan that is at least about 40 ng/mL.
5. The method of claim 1 , wherein on the eighth day that the dosage form is orally administered twice a day, the human being has a C max of dextromethorphan that is at least about 50 ng/mL.
6. The method of claim 1 , wherein on the eighth day that the dosage form is orally administered twice a day, the human being has an AUC 0-12 of dextromethorphan that is at least about 500 ng·hr/mL.
7. A method of increasing dextromethorphan plasma levels in a human being, comprising orally administering, twice a day, a dosage form comprising bupropion and dextromethorphan to the human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the dosage form contains about 100 mg to about 200 mg of the bupropion and about 40 mg to about 60 mg of the dextromethorphan, wherein the dosage form is orally administered twice a day for at least eight consecutive days, and wherein on the eighth day that the dosage form is orally administered twice a day, the human being has an AUC 0-12 of dextromethorphan that is at least about 15 times the AUC 0-12 that would be achieved by orally administering the same amount of the dextromethorphan without the bupropion twice a day for eight consecutive days.
8. The method of claim 7 , wherein on the eighth day that the dosage form is orally administered twice a day, the human being has an AUC 0-12 of dextromethorphan that is at least about 20 times the AUC 0-12 that would be achieved by orally administering the same amount of the dextromethorphan without the bupropion twice a day for eight consecutive days.
9. The method of claim 7 , wherein the bupropion and the dextromethorphan are in separate domains, layers, or phases within the dosage form.
10. The method of claim 9 , wherein the domain, the layer, or the phase containing the bupropion provides sustained release of bupropion and the domain, the layer, or the phase containing the dextromethorphan provides immediate release of dextromethorphan.
11. The method of claim 7 , wherein the human being is at risk of experiencing an adverse event as a result of being treated with dextromethorphan.
12. The method of claim 7 , wherein the human being is at risk of experiencing an adverse event as a result of being treated with bupropion.
13. The method of claim 7 , wherein the dosage form is orally administered twice a day for at least 30 consecutive days.
14. A method of increasing dextromethorphan plasma levels in a human being, comprising orally administering a dosage form comprising bupropion and dextromethorphan to the human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the dosage form contains about 100 mg to about 200 mg of the bupropion and about 40 mg to about 60 mg of the dextromethorphan, wherein the dosage form is orally administered for at least eight consecutive days, wherein the dosage form is orally administered once or twice a day, and wherein on the eighth day that the dosage form is orally administered, the human being has an AUC 0-12 of dextromethorphan that is at least about 15 times the AUC 0-12 that would be achieved by orally administering the same amount of the dextromethorphan without the bupropion for eight consecutive days.
15. The method of claim 14 , wherein the dosage form contains about 42 mg to about 48 mg of the dextromethorphan and about 100 mg to about 140 mg of the bupropion.
16. The method of claim 14 , wherein on the eighth day that the dosage form is orally administered, the human being has an AUC 0-12 of dextromethorphan that is at least about 20 times the AUC 0-12 that would be achieved by orally administering the same amount of the dextromethorphan without the bupropion for eight consecutive days.
17. The method of claim 14 , wherein the dextromethorphan or the bupropion is deuterium-modified.
18. The method of claim 1 , wherein the human being is at risk of experiencing an adverse event as a result of being treated with bupropion.
19. The method of claim 14 , wherein the human being is at risk of experiencing an adverse event as a result of being treated with bupropion.