METHOD OF INDUCING SELECTIVE PROSTATE GLANDULAR PHARMACO-ABLATION WITH SPARING OF NERVES AND PRESERVATION OF SEXUAL FUNCTION
Disclosed are methods of selective glandular pharmaco-ablation using compositions containing compounds based on small peptides and a pharmaceutically acceptable carrier. The methods of selectively destroying prostate gland overgrowth substantially or completely preserve key nerve, stromal, vascular, connective tissue, urethral musculature, and structural elements in intimate structural proximity to the foci of ablation.
1 . A method of selectively destroying gland overgrowth comprising administering Fexapotide Triflutate to a patient in need thereof in an amount sufficient to treat a substantial portion of the prostate gland; and selectively destroying gland overgrowth, while substantially preserving nerve, stromal, vascular, and connective tissue, and urethral musculature in intimate structural proximity to the loci of administration.
2 . The method of claim 1 , wherein the method comprises administration of Fexapotide Triflutate as claimed in claim 1 and a carrier.
3 . The method of claim 1 , wherein the method comprises administration of Fexapotide Triflutate within the range of from about 0.04 to about 4 mg per kg of mammal body weight.
4 . The method of claim 3 , wherein the method comprises administration of Fexapotide Triflutate within the range of from about 0.05 to about 3 mg per kg of mammal body weight.
5 . The method of claim 3 , wherein the method comprises administration of Fexapotide Triflutate within the range of from about 0.06 to about 1.7 mg per kg of mammal body weight.
6 . The method of claim 3 , wherein the method comprises administration of Fexapotide Triflutate within the range of from about 0.12 to about 4 mg per kg of mammal body weight.
7 . The method of claim 1 , wherein the method comprises administration of Fexapotide Triflutate more than once at different locations in the prostate gland.
8 . The method of claim 1 , wherein the method comprises administration of Fexapotide Triflutate in an amount of less than about 0.04 to about 4 mg per kg of mammal body weight once a week for a period of from two weeks to 8 weeks.
9 . The method of claim 8 , wherein the method comprises administration of Fexapotide Triflutate in an amount of less than about 0.04 to about 4 mg per kg of mammal body weight once a week for a period of from two weeks to 4 weeks.
10 . The method of claim 1 , wherein the method comprises administration of Fexapotide Triflutate in an amount of less than about 0.04 to about 4 mg per kg of mammal body weight once a month for a period of from two months to 6 months.
11 . The method of claim 10 , wherein the method comprises administration of Fexapotide Triflutate in an amount of less than about 0.04 to about 4 mg per kg of mammal body weight once a month for a period of from two months to 4 months.
12 . The method of claim 1 , wherein the method comprises administration of Fexapotide Triflutate more than once.
13 . The method of claim 12 , wherein the period of time between administration of the Fexapotide Triflutate is within the range of from about 2 months to about 10 years.
14 . The method of claim 13 , wherein the period of time between administration of the Fexapotide Triflutate is within the range of from about 8 months to about 4 years.
15 . The method of claim 13 , wherein the period of time between administration of the Fexapotide Triflutate is within the range of from about 1 year to about 2 years.
16 . The method of claim 1 , wherein Fexapotide Triflutate is administered by a method selected from the group consisting of orally, subcutaneously, intradermally, intranasally, intravenously, intramuscularly, intrathecally, intranasally, intratumorally, topically, transrectally, transperitoneally, and transdermally.
17 . The method of claim 1 , wherein the method shrinks the prostate gland volume by an amount within the range of from about 15% to about 75% per single dose.
18 . The method of claim 5 , wherein the method shrinks the prostate gland volume by an amount within the range of from about 33% to about 48%.