Transdermal microneedle continuous monitoring system
Transdermal microneedles continuous monitoring system is provided. The continuous system monitoring includes a substrate, a microneedle unit, a signal processing unit and a power supply unit. The microneedle unit at least comprises a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, the first and second microneedle sets arranging on the substrate. Each microneedle set comprises at least a microneedle. The first microneedle set comprises at least a sheet having a through hole on which a barbule forms at the edge. One of the sheets provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately.
1. A transdermal microneedles continuous monitoring system, comprising:
a substrate;
a microneedle unit comprising at least a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, each of the microneedle sets comprising at least a microneedle, the first microneedle set comprising at least two sheets, each of the sheets having a through hole defined thereon and a barbule arranged at the peripheral of the through hole, the through hole on one sheet allowing the corresponding barbules of an other sheet to pass and the barbules being disposed separately;
a test strip arranged between the first microneedle set and the substrate, wherein the test strip comprises a conductive layer and a plurality of test areas on the conductive layer, and each of the test areas is coated with sensing polymer and aligned with each of the through holes of the first microneedle set, respectively;
a signal processing unit arranged on the substrate and electrically connecting to the first microneedle set and the second microneedle set; and
a power supply unit providing working power to the transdermal microneedles continuous monitoring system,
wherein the at least two sheets comprise a first sheet, a second sheet and a third sheet stacked with each other, the first sheet having at least one first through hole defined thereon and a first barbule at the peripheral of the first through hole, the second sheet having at least one second through hole defined thereon and a second barbule at the peripheral of the second through hole, the third sheet having at least one third through hole defined thereon and a third barbule at the peripheral of the third through hole, wherein the second barbule and the third barbule penetrate the first through hole to juxtapose the first barbule, and tips of the barbules are in triangular arrangement.
2. The transdermal microneedles continuous monitoring system in claim 1 , wherein each of the barbule of the first microneedle set comprises a tip and a base, wherein the tips of the barbules are not at the same altitudes after the sheets are stacked and the through hole of one sheet are penetrated by the barbules of other sheets.
3. The transdermal microneedles continuous monitoring system in claim 1 , wherein each of the barbule of the first microneedle set comprises a tip and a base, wherein the tips of the barbules are at the same altitudes after the sheets are stacked and the through hole of one sheet are penetrated by the barbules of other sheets.
4. The transdermal microneedles continuous monitoring system in claim 1 , wherein the microneedles of first microneedle set and the second microneedle set are formed by punching or etching.
5. The transdermal microneedles continuous monitoring system in claim 1 , wherein each the barbules has sensing polymer coated on inner surface thereof.
6. The transdermal microneedles continuous monitoring system in claim 5 , further comprising a protection layer on the sensing polymer.
7. The transdermal microneedles continuous monitoring system in claim 1 , wherein each the barbules has anti-irritation medicine coated on outer surface thereof.
8. The transdermal microneedles continuous monitoring system in claim 7 , further comprising a protection layer on the anti-irritation medicine.