IL2R common gamma chain antibodies
Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
1. An isolated antibody or antigen binding fragment which specifically binds to common γ chain (γc), and comprises:
(i) a light chain variable region comprising the following CDRs:
LC-CDR1:
(SEQ ID NO: 68)
RSSQSLLHSNGYNYLD
LC-CDR2:
(SEQ ID NO: 69)
LGSNRDS
LC-CDR3:
(SEQ ID NO: 70)
MQGTHWPWT;
and
(ii) a heavy chain variable region comprising the following CDRs:
HC-CDR1:
(SEQ ID NO: 48)
GYYWS
HC-CDR2:
(SEQ ID NO: 49)
EINHSGSTNYNPSLKS
HC-CDR3:
(SEQ ID NO: 77)
SPGGYSGGYFQH.
2. The isolated antibody or antigen binding fragment according to claim 1 , wherein:
the light chain variable region sequence has at least 70% sequence identity to SEQ ID NO:67, and
the heavy chain variable region sequence has at least 70% sequence identity to SEQ ID NO:76.
3. The isolated antibody or antigen binding fragment according to claim 1 , wherein:
the light chain variable region sequence has at least 85% sequence identity to SEQ ID NO:67, and
the heavy chain variable region sequence has at least 85% sequence identity to SEQ ID NO:76.
4. The isolated antibody or antigen binding fragment according to claim 1 , conjugated to a drug moiety or a detectable moiety.
5. A bispecific antibody comprising the antibody or antigen binding fragment of claim 1 .