Compounds for use in wound healing and angiogenesis
Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of at least one of a flavonoid and a chlorogenic acid that are natural extracts of Parrotia persica , or their derivatives, analogues, or homologs. Compounds based upon these natural extracts have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.
1. A method for treatment of a wound, the method comprising contacting the wound with a composition, the composition comprising a total extract of Parrotia persica.
2. The method of claim 1 , wherein the wound comprises an acute wound, a chronic wound, or a burn.
3. The method of claim 1 , wherein the composition is applied during one or more additional wound phases.
4. The method of claim 1 , wherein the composition is carried by a pharmaceutical appliance.
5. The method of claim 4 , the pharmaceutical appliance comprising a suture, a stable, gauze, a bandage, a solid wound dressing, or an artificial skin.
6. The method of claim 1 , the composition being in the form of a gel, a cream, or an ointment.
7. The method of claim 1 , wherein the composition is contained within a capsule.
8. The method of claim 1 , the composition further comprising one or more of quinic acid, 1-O-caffeoylquinic acid, 4-O-caffeoylqunic acid, 5-O-caffeoylquinic acid, 1,5-O-dicaffeoylquinic acid, 1,3-O-dicaffeoylquinic acid, 3,4-O-dicaffeoylquinic acid, 3,5-O-dicaffeoylquinic acid, 4,5-O-dicaffeoylquinic acid, and 3,4,5-O-tetracaffeoylquinic acid, 3,4,5-O-tricaffeoylquinic acid.
9. The method of claim 1 , the composition further comprising one or more of myricetin, myricetin-3-O-glucoside, quercetin, quercetin-3-O-glucoside, quercetin-3-O-rhamnoside, kaempferol, kaempferol-3-O-rhamnoside, kaempferol-3-O-glucoside, and luteolin-7-O-glucoside.
10. The method of claim 1 , the total extract of Parrotia persica comprising myricetin-3-O-rhamnoside and 3-O-caffeoylquinic acid.
11. The method of claim 10 , the composition comprising the myricetin-3-O-rhamnoside in an amount of from about 0.00001% to about 5% by weight of the composition.
12. The method of claim 10 , the composition comprising the 3-O-caffeoylquinic acid in an amount of from about 0.00001% to about 5% by weight of the composition.
13. The method of claim 1 , the composition comprising the total extract of Parrotia persica in an amount of from 10 μg/ml to 100 μg/ml.
14. The method of claim 1 , the wound comprising Adult Normal Human Epidermal Keratinocytes or Normal Human Dermal Fibroblasts.
15. The method of claim 1 , wherein the wound is a chronic wound.
16. The method of claim 1 , wherein the wound is a bedsore.
17. The method of claim 1 , wherein the wound is a wound to an internal tissue.