Surgical system and procedure for precise intraocular pressure reduction

1. A method of treating glaucoma in an eye comprising an anterior chamber, a Schlemm's canal, and a trabecular meshwork therebetween comprising a uveal layer, a corneoscleral meshwork, and a juxtacanalicular tissue, the method comprising:

designing an initial treatment pattern that defines an initial volume of ocular tissue to be modified based on an aqueous flow model comprising discrete sets of electrical circuit components, each discrete set modeling one of the uveal layer, the corneoscleral meshwork, and the juxtacanalicular tissue;

delivering an initial laser treatment by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue;

evaluating a postoperative measure of intraocular pressure (IOP) relative to an IOP criterion; and

when the IOP criterion is not satisfied:

determining a subsequent treatment pattern that defines a subsequent volume of ocular tissue to be modified, and a subsequent placement in the eye,

delivering a subsequent laser treatment by scanning a laser beam across ocular tissue at the subsequent placement within the eye in accordance with the subsequent treatment pattern to thereby photo disrupt the subsequent volume of ocular tissue, and

repeating the evaluating.

2. The method of claim 1 , wherein designing an initial treatment pattern comprises:

obtaining a plurality of preoperative outflow parameters of the eye to be treated;

applying one or more of the plurality of preoperative outflow parameters to the aqueous flow model;

modifying the aqueous flow model based on a test treatment pattern;

obtaining a model IOP based on the modified aqueous flow model;

evaluating the model IOP relative to the IOP criterion to obtain an evaluation outcome;

when the evaluation outcome is positive, designating the test treatment pattern as the initial treatment pattern; and

when the evaluation outcome is negative,

modifying the aqueous flow model based on a modified test treatment pattern, and

repeating the obtaining and the evaluating.

3. The method of claim 2 , wherein the plurality of preoperative output flow parameters comprises a measure of hydraulic flow resistance of the Schlemm's canal and obtaining the measure comprises:

measuring a cross sectional dimension of the Schlemm's canal; and

applying a hydrodynamic flow equation for laminar flow of aqueous humor within the Schlemm's canal based on the measured cross sectional dimension.

4. The method of claim 3 , wherein the cross sectional dimension of the Schlemm's canal is obtained from at least one of a light microscopy image and an optical coherence tomography (OCT) image of the eye.

5. The method of claim 2 , wherein the plurality of preoperative output flow parameters comprises one or more of a measure of IOP, and a measure of collective hydraulic conductivity.

6. The method of claim 2 , wherein obtaining a model IOP based on the modified aqueous flow model comprises determining a hydraulic flow resistance through the trabecular meshwork.

7. The method of claim 2 , wherein the IOP criterion corresponds to either of a target measure of IOP or a target reduction in IOP, and evaluating the model IOP relative to an IOP criterion comprises:

determining the evaluation outcome is positive when the model IOP is less than or equal to the target measure of IOP; and

determining the evaluation outcome is positive when the difference between the model IOP and a preoperative measure of IOP is greater than or equal to the target reduction in IOP.

8. The method of claim 1 , wherein modifying the aqueous flow model based on a test treatment pattern comprises setting a value of one or more electrical circuit components equal to zero.

9. The method of claim 8 , wherein the one or more electrical circuit components are in a same one of the discrete sets of electrical circuit components.

10. The method of claim 8 , wherein the one or more electrical circuit components are distributed among at least two of the discrete sets of electrical circuit components.

11. A method of treating glaucoma in an eye comprising an anterior chamber, a Schlemm's canal, and a trabecular meshwork therebetween comprising a uveal layer, a corneoscleral meshwork, and a juxtacanalicular tissue, the method comprising:

designing an initial treatment pattern that defines an initial volume of ocular tissue to be modified based on an aqueous flow model comprising discrete sets of electrical circuit components, each discrete set modeling one of the uveal layer, the corneoscleral meshwork, and the juxtacanalicular tissue;

delivering an initial laser treatment by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue;

evaluating a postoperative measure of intraocular pressure (IOP) relative to an IOP criterion; and

obtaining a postoperative measure of IOP by:

obtaining a plurality of IOP measures at different times within a period after the initial laser treatment; and

deriving the postoperative measure of IOP based on the plurality of IOP measures.

12. A method of treating glaucoma in an eye comprising an anterior chamber, a Schlemm's canal, and a trabecular meshwork therebetween comprising a uveal layer, a corneoscleral meshwork, and a juxtacanalicular tissue, the method comprising:

designing an initial treatment pattern that defines an initial volume of ocular tissue to be modified based on an aqueous flow model comprising discrete sets of electrical circuit components, each discrete set modeling one of the uveal layer, the corneoscleral meshwork, and the juxtacanalicular tissue;

delivering an initial laser treatment by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue;

evaluating a postoperative measure of intraocular pressure (IOP) relative to an IOP criterion; and

wherein the IOP criterion corresponds to either of a target measure of IOP or a target reduction in IOP, and evaluating the postoperative measure of IOP relative to an IOP criterion comprises:

determining the IOP criterion is satisfied when the postoperative measure of IOP is less than or equal to the target measure of IOP; and

determining the IOP criterion is satisfied when the difference between the postoperative measure of IOP and a preoperative measure of IOP is greater than or equal to the target reduction in IOP.

13. A method of treating glaucoma in an eye comprising an anterior chamber, a Schlemm's canal, and a trabecular meshwork therebetween comprising a uveal layer, a corneoscleral meshwork, and a juxtacanalicular tissue, the method comprising:

designing an initial treatment pattern that defines an initial volume of ocular tissue to be modified based on an aqueous flow model comprising discrete sets of electrical circuit components, each discrete set modeling one of the uveal layer, the corneoscleral meshwork, and the juxtacanalicular tissue;

delivering an initial laser treatment by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue;

evaluating a postoperative measure of intraocular pressure (IOP) relative to an IOP criterion; and

wherein the initial treatment pattern is defined by a set of surgical parameters comprising an area and a thickness, and determining a subsequent treatment pattern comprises modifying one or more of the area or the thickness.

14. A method of treating glaucoma in an eye comprising an anterior chamber, a Schlemm's canal, and a trabecular meshwork therebetween comprising a uveal layer, a corneoscleral meshwork, and a juxtacanalicular tissue, the method comprising:

designing an initial treatment pattern that defines an initial volume of ocular tissue to be modified based on an aqueous flow model comprising discrete sets of electrical circuit components, each discrete set modeling one of the uveal layer, the corneoscleral meshwork, and the juxtacanalicular tissue;

delivering an initial laser treatment by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue;

evaluating a postoperative measure of intraocular pressure (IOP) relative to an IOP criterion; and

wherein the initial placement in the eye is defined by a set of placement parameters comprising a location around a circumferential angle of the eye and a depth within the eye relative to an eye structure, and determining a subsequent placement in the eye comprises modifying one or more of the location or the depth.

15. A system for treating glaucoma in an eye comprising a cornea, an anterior chamber, a Schlemm's canal, and a trabecular meshwork therebetween comprising a uveal layer, a corneoscleral meshwork, and a juxtacanalicular tissue, the system comprising:

a first optical subsystem including a focusing objective configured to be coupled to the cornea;

a second optical subsystem including: a laser source configured to output a laser beam, and a plurality of components configured to one or more of condition, scan, and direct the laser beam through the focusing objective; and

a control system coupled to the second optical subsystem and configured to:

design an initial treatment pattern that defines an initial volume of ocular tissue to be modified based on an aqueous flow model comprising discrete sets of electrical circuit components, each discrete set modeling one of the uveal layer, the corneoscleral meshwork, and the juxtacanalicular tissue;

instruct the laser source to deliver an initial laser treatment by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue;

evaluate a postoperative measure of IOP relative to an IOP criterion; and

when the IOP criterion is not satisfied:

determine a subsequent treatment pattern that defines a subsequent volume of ocular tissue to be modified, and a subsequent placement in the eye,

instruct the laser source to deliver a subsequent laser treatment by scanning a laser beam across ocular tissue at the subsequent placement within the eye in accordance with the subsequent treatment pattern to thereby photo disrupt the subsequent volume of ocular tissue, and

repeat the evaluating.

16. The system of claim 15 , wherein the control system designs an initial treatment pattern by being further configured to:

apply one or more of a plurality of preoperative outflow parameters of the eye to an aqueous flow model;

modify the aqueous flow model based on a test treatment pattern;

obtain a model IOP based on the modified aqueous flow model;

evaluate the model IOP relative to the IOP criterion to obtain an evaluation outcome;

when the evaluation outcome is positive, designate the test treatment pattern as the initial treatment pattern; and

when the evaluation outcome is negative, modify the aqueous flow model based on a modified test treatment pattern, and repeat the obtaining and the evaluating.

17. The system of claim 16 , wherein the plurality of preoperative output flow parameters comprises a measure of hydraulic flow resistance of the Schlemm's canal, and the control system is configured to obtain the measure by being configured to:

measure a cross sectional dimension of the Schlemm's canal; and

apply a hydrodynamic flow equation for laminar flow of aqueous humor within the Schlemm's canal based on the measured cross sectional dimension.

18. The system of claim 17 , wherein the second optical subsystem includes at least one of an optical coherence tomography (OCT) imaging apparatus configured to output an OCT beam and a visual observation apparatus, and the cross sectional dimension of the Schlemm's canal is measured by the control system from at least one of a light microscopy image received from the visual observation apparatus and an OCT image received from the OCT imaging apparatus.

19. The system of claim 16 , wherein the plurality of preoperative output flow parameters comprises one or more of a measure of IOP, and a measure of collective hydraulic conductivity.

20. The system of claim 16 , wherein the control system obtains a model IOP based on the modified aqueous flow model by being further configured to determine a hydraulic flow resistance through the trabecular meshwork.

21. The system of claim 16 , wherein the IOP criterion corresponds to either a target measure of IOP or a target reduction in IOP, and the control system evaluates the model IOP relative to an IOP criterion by being further configured to:

determine the evaluation outcome is positive when the model IOP is less than or equal to the target measure of IOP; and

determine the evaluation outcome is positive when the difference between the model IOP and a preoperative measure of IOP is greater than or equal to the target reduction in IOP.

22. The system of claim 16 , wherein the control system is configured to:

obtain a plurality of IOP measures at different times within a period after the initial laser treatment; and

derive the postoperative measure of IOP based on the plurality of IOP measures.

23. The system of claim 16 , wherein the IOP criterion corresponds to either a target measure of IOP or a target reduction in IOP, and the control system evaluates the postoperative measure of IOP relative to an IOP criterion by being further configured to:

determine the IOP criterion is satisfied when the postoperative measure of IOP is less than or equal to the target measure of IOP; and

determine the IOP criterion is satisfied when the difference between the postoperative measure of IOP and a preoperative measure of IOP is greater than or equal to the target reduction in IOP.

24. The system of claim 16 , wherein the initial treatment pattern is defined by a set of surgical parameters comprising an area and a thickness, and determining a subsequent treatment pattern comprises modifying one or more of the area or the thickness.

25. The system of claim 13 , wherein the initial placement in the eye is defined by a set of placement parameters comprising a location around a circumferential angle of the eye and a depth within the eye relative to an eye structure, and determining a subsequent placement in the eye comprises modifying one or more of the location or the depth.