System and method for laser treatment of ocular tissue using non-collinear imaging
A method of treating an eye includes delivering an OCT beam along an OCT optical path that enters a first optical subsystem along an input axis, and exits the first optical subsystem along an output axis that: 1) is substantially parallel to the optical axis of the eye, 2) is radially offset from the optical axis, and 3) extends through the cornea and into a portion of the irido-corneal angle at a point along a circumferential angle of the eye. The method also includes imaging the portion of the irido-corneal angle with the OCT beam; delivering a laser beam along an angled optical path that extends through the first optical subsystem, through the cornea, through the anterior chamber, and into a target volume of ocular tissue in the portion of the irido-corneal angle; and photodisrupting at least a portion of the target volume of ocular tissue with the laser beam.
1 . An integrated surgical system for imaging and treating an eye having an optical axis, a cornea, an anterior chamber, and an irido-corneal angle, the integrated surgical system comprising:
a laser source configured to output a laser beam;
an OCT imaging apparatus configured to output an OCT beam;
a first optical subsystem configured to:
couple to the eye,
receive the OCT beam along an OCT input axis incident to an entry face of the first optical subsystem, and to direct the OCT beam along an OCT optical path through the first optical subsystem to an OCT output axis that: 1) is within 20 degrees of parallel to the optical axis of the eye, 2) is radially offset from the optical axis of the eye, and 3) extends through the cornea and into a portion of the irido-corneal angle at a point along a circumferential angle of the eye while avoiding the anterior chamber, and
receive the laser beam along a laser input axis incident to an entry surface of the first optical subsystem, and to direct the laser beam along an angled optical path through the first optical subsystem, through the cornea, through the anterior chamber, and into a target volume of ocular tissue in the portion of the irido-corneal angle, wherein the angled optical path is different from the OCT optical path;
a second optical subsystem optically coupled to the laser source, the OCT imaging apparatus, and the first optical subsystem and configured to:
deliver the laser beam to the first optical subsystem along the laser input axis, and
deliver the OCT beam to the first optical subsystem along the OCT input axis; and
a control system coupled to the laser source, the OCT imaging apparatus, and the second optical subsystem and configured to:
control the OCT imaging apparatus to output the OCT beam to the second optical subsystem, and to image the portion of the irido-corneal angle with the OCT beam, and
control the laser source to output the laser beam to the second optical subsystem to photodisrupt at least a portion of the target volume of ocular tissue.
2 . The integrated surgical system of claim 1 , wherein the first optical subsystem comprises an entry face and the first optical subsystem is:
arranged to receive the OCT beam along the OCT input axis incident to the entry face, and
configured to direct the OCT beam to the OCT output axis.
3 . The integrated surgical system of claim 2 , wherein the first optical subsystem is configured to provide a linear optical path along the OCT input axis to the OCT output axis.
4 . The integrated surgical system of claim 2 , wherein the first optical subsystem comprises at least one reflective facet and is configured to reflect the OCT beam off the at least one reflective facet to the OCT output axis.
5 . The integrated surgical system of claim 1 , wherein the first optical subsystem comprises a subsystem axis and is configured so that when coupled to the eye, the subsystem axis is substantially aligned with the optical axis of the eye and the OCT output axis is radially offset from the subsystem axis.
6 . The integrated surgical system of claim 1 , wherein the first optical subsystem comprises a subsystem axis, an entry face, and an entry surface spaced apart from the entry face, and the first optical subsystem is:
arranged to receive the OCT beam incident the entry face; and
receive the laser beam incident the entry surface.
7 . The integrated surgical system of claim 6 , wherein the entry face is substantially flat, and the entry surface is convex curved.
8 . The integrated surgical system of claim 1 , wherein the first optical subsystem comprises a subsystem axis and one or more optics configured to rotate about the subsystem axis.
9 . The integrated surgical system of claim 8 , wherein the one or more optics comprises a window and an exit lens having a surface coupled to the window, and the exit lens is configured to rotate about the subsystem axis without rotating the window.
10 . The integrated surgical system of claim 1 , wherein the first optical subsystem comprises a subsystem axis, and the angled optical path and the subsystem axis are angularly offset from each other.
11 . The integrated surgical system of claim 1 , wherein the OCT output axis and the angled optical path are angularly offset from each other.
12 . The integrated surgical system of claim 1 , wherein:
the first optical subsystem comprises a subsystem axis and an entry surface, and the first optical subsystem is:
arranged to receive the
laser beam along a laser input axis incident the entry surface and
angularly offset from the subsystem axis.
13 . The integrated surgical system of claim 1 , further comprising a visualization observation subsystem configured to output an illumination beam and to receive a visual observation beam,
wherein the first optical subsystem is arranged and configured to direct each of the illumination beam and the visual observation beam along one of the OCT optical path and the angled optical path.