Composition for inhibiting immune cell proliferation comprising sialyllactose or derivative thereof and method thereof
Provided are a composition for inhibiting immune cell proliferation, including sialyllactose or a derivative thereof as an active ingredient, and a method of inhibiting immune cell proliferation, wherein the composition and the method may decrease expression of chemokines, decrease expression of pro-inflammatory cytokines, decrease production of inflammatory mediators, decrease expression of COX2, and decrease production of PEG 2 , and therefore, may be useful for the prevention or treatment of atopic dermatitis or arthritis.
1. A method of promoting cartilage formation or inhibiting cartilage destruction in osteoarthritis, the method comprising administering a therapeutically effective amount of a composition comprising sialyllactose or a pharmaceutically acceptable salt thereof as an active ingredient to a patient in need thereof,
wherein the effective amount is determined by increased expression of type II collagen (Col2a1), increased Sox-9 activity, and/or decreased expression of matrix metalloproteinase3 (Mmp3) or matrix metalloproteinase13 (Mmp13).
2. The method of claim 1 , wherein the method has therapeutic effects on osteoarthritis.
3. The method of claim 1 , wherein the sialyllactose is 3′-sialyllactose or 6′-sialyllactose.
4. The method of claim 3 , wherein the salt of 3′-sialyllactose has a structure of the following Formula 1:
5. The method of claim 3 , wherein the salt of 6′-sialyllactose has a structure of the following Formula 2:
6. The method of claim 1 , wherein the method has one or more of the following characteristics of:
increasing Sox-9 activity; and
increasing inactivation of p-ERK.