Medical adhesives for stopping heavy bleeding and sealing leakages
The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.
1. A formulation for staunching the loss of blood (haemostatic) or tissue fluids comprising:
A) an isocyanate-functional prepolymer obtained from
A1) an aliphatic isocyanate and
A2) a polyol component having a number-average molecular weight of greater than or equal to 400 g/mol and an average OH functionality of 2 to 6,
B) a curing component comprising
B1) an amino-functional aspartic ester of the general formula (I)
where
X is an organic radical obtained by removing the primary amino groups from 2-methyl 1,5-diaminopentane;
R 1 and R 2 are ethyl and
n is 2;
B2) optionally, organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range from 10 to 6000 mPas,
and
C) optionally, reaction products of isocyanate-functional prepolymers as defined for component A) with aspartic esters as per component B1) and/or organic fillers as per component B2).
2. The formulation according to claim 1 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas.
3. The formulation according to claim 2 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the organic fillers.
4. The formulation according to claim 1 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester.
5. The formulation according to claim 4 , wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with organic fillers.
6. The formulation according to claim 1 , wherein the curing component further comprises organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range of from 10 to 6000 mPas and wherein the formulation further comprises reaction products of the isocyanate-functional prepolymer with the amino-functional aspartic ester and the organic fillers.
7. The formulation according to claim 1 , wherein the polyol component has a number-average molecular weight of 4000 to 8500 g/mol.
8. The formulation according to claim 1 , wherein the polyol component comprises a polyalkylene oxide polyether.
9. The formulation according to claim 8 , wherein the polyalkylene oxide polyether contains from 60% to 90% of ethylene oxide-based units, based on the total amount of alkylene oxide units.
10. The formulation according to claim 2 , wherein the organic fillers comprise polyether polyols.
11. The formulation according to claim 1 , wherein the formulation is curable for a period of time from 30 seconds to 10 minutes.
12. The formulation according to claim 1 , wherein the formulation is curable for a period of time from 30 seconds to 2 minutes.