Anti-microbial bandage contact lens with ocular drug delivery
The technology relates to a prophylactic bandage contact lens that prevents microbial infections in an eye as well as treats infection by dispensing antimicrobial medication at controlled rates. In one embodiment, the invention provides a bandage with nanostructures, and provides a continuous treatment over 10 days and shields the eye from the environment, significantly diminishing the risk of infection while allowing damaged tissues to heal.
1. A bandage contact lens, comprising:
a first and a second layers, the first and the second layers each having an inner surface and an outer surface and each comprising an array of nanopillars characterized by antimicrobial properties disposed on at least the outer surface; and
a void space enclosed by the inner surfaces of the first and the second layers.
2. The bandage contact lens of claim 1 , wherein the first and the second layers comprise an inherently antimicrobial material.
3. The bandage contact lens of claim 1 , wherein the array of nanopillars is characterized by a nanopillar diameter, a nanopillar periodicity, and a nanopillar height.
4. The bandage contact lens of claim 2 , wherein the inherently antimicrobial material comprises chitosan.
5. The bandage contact lens of claim 3 , wherein the nanopillar diameter is at least 100 nm.
6. The bandage contact lens of claim 1 , wherein the void space is filled with a transparent material that elutes at least one drug.
7. The bandage contact lens of claim 1 , wherein the void space is filled with a composite material comprising a hydrogel matrix reinforced with nanofibers.
8. The bandage contact lens of claim 6 , wherein the at least one drug is eluted continuously.
9. The bandage contact lens of claim 6 , wherein the at least one drug is selected from the group consisting of:
natamycin, voriconazole, and erythromycin.
10. The bandage contact lens of claim 1 , wherein the bandage contact lens is transparent.
11. The bandage contact lens of claim 7 , wherein the hydrogel matrix comprises a material selected from the group consisting of:
chitosan, gelatin, and any combination thereof.
12. The bandage contact lens of claim 7 , wherein the nanofibers comprise chitin nanofibers.
13. The bandage contact lens of claim 7 , wherein the composite material provides strength, stability, and shape for the bandage contact lens.
14. The bandage contact lens of claim 1 , wherein the first and the second layers comprise a lubricating hydrogel.
15. The bandage contact lens of claim 1 , wherein the first and the second layers comprise a transparent, flexible and or soft material suitable for fabrication of eye contact lenses.
16. The bandage contact lens of claim 7 , wherein the bandage contact lens is transparent.
17. The bandage contact lens of claim 1 , wherein the first and the second layers comprise poly(methyl methacrylate.
18. A device, comprising an antimicrobial bandage contact lens comprising:
a first and a second layers, the first and the second layers each having an inner surface and an outer surface and each comprising an array of nanopillars characterized by antimicrobial properties disposed on at least the outer surface; and
a void space enclosed by the inner surfaces of the first and the second layers;
wherein the antimicrobial bandage contact lens shields an eye afflicted by a medical condition from an environment during a treatment of the medical condition.
19. The device of claim 18 , wherein the first and the second layers comprise an inherently antimicrobial material, and the antimicrobial bandage contact lens acts as a prophylactic device that prevents microbial infections in the eye.
20. The device of claim 18 , wherein the void space is filled with a transparent material that elutes at least one drug at a controlled rate over a period of up to 10 days or longer.
21. The device of claim 18 , wherein the antimicrobial bandage contact lens is transparent.
22. The device of claim 18 , wherein the void space is filled with a transparent composite material comprising a hydrogel matrix reinforced with nanofibers, and wherein the transparent composite material provides strength, stability, and shape for the antimicrobial bandage contact lens.
23. The device of claim 18 , wherein the first and the second layers comprise a transparent, flexible and or soft material suitable for fabrication of eye contact lenses.
24. The device of claim 18 , wherein the array of nanopillars is characterized by a nanopillar diameter of at least 100 nm.