METHOD OF TREATING PAIN
The instant application discloses methods of treating, reducing, or preventing pain in a mammal, which may include administering a compound capable of modulating a transient receptor potential channel. In one aspect, the TRP channel may be TRPC4. Types of pain contemplated by the present disclosure include acute, chronic, neuropathic, and nociceptive pain.
1 . A compound selected from
a)
wherein R is selected from
wherein R′ is selected from H, CH 3 , Et, or X, and
wherein R″ is selected from H or alkyl;
for use in a method for treating the human or animal body.
2 . The compound of claim 1 , wherein R is
wherein R′ is selected from H, CH 3 , Et, or X, and
wherein R″ is selected from H or alkyl.
3 . The compound of claim 1 or 2 , wherein R is
R′ is H, and R″ is CH 3 .
4 . The compound of any of claims 1 to 3 for use in treating, reducing, or preventing pain in a mammal.
5 . The compound of claim 4 , wherein the pain is selected from acute, chronic, neuropathic, nociceptive and visceral pain, and a combination thereof.
6 . The compound of claim 5 , wherein the pain comprises visceral pain.
7 . The compound of claim 5 , wherein the pain comprises neuropathic pain.
8 . The compound of any of claims 4 to 7 , wherein said compound is administered orally.
9 . The compound of any of claims 4 to 7 , wherein said compound is administered topically.
10 . A pharmaceutical composition comprising the compound of any of claims 1 to 7 and a pharmaceutical excipient.
11 . The pharmaceutical composition of claim 8 , further comprising one or more additional pharmaceutically active agents.
12 . The pharmaceutical composition of claim 9 , wherein said one or more additional pharmaceutically active agents are selected from non-opioid analgesics, opioid analgesics, anti-epileptics, NMDA antagonists, lidocaine, tricyclic antidepressants, or a combination thereof.
13 . A method of treating, reducing, or preventing pain in a mammal, comprising the step of administering a therapeutically effective amount of a composition to said mammal, wherein said composition comprises a compound selected from
a)
wherein R is selected from
wherein R′ is selected from H, CH 3 , Et, or X, and
wherein R″ is selected from H or alkyl;
b)
wherein R is selected from Aryl, heteroaryl, alkyl, cycloalkyl, H, and R′ is selected from H, aryl, heteroaryl, alkyl, cycloalkyl to a subject in need thereof, and wherein said compound is capable of modulating Trpc4 activity.
14 . The method of claim 13 , wherein said compound comprises
wherein R is
wherein R′ is selected from H, CH 3 , Et, or X, and
wherein R″ is selected from H or alkyl.
15 . The method of claim 13 or 14 , wherein said compound comprises
wherein R is
R′ is H, and R″ is CH 3 .
16 . The method of any of claims 13 to 15 , wherein said Trpc4 is human.
17 . The method of any of claims 13 to 16 , wherein said compound causes an increase in Trpc4 activity.
18 . The method of any of claims 13 to 16 , wherein said compound causes a decrease in Trpc4 activity.
19 . The method of any of claims 13 to 16 , wherein said compound functions as a Trpc4 antagonist.
20 . The method of claims 13 to 16 , wherein said compound functions as a Trpc4 agonist.
21 . The method of claim 14 , wherein said compound functions as a Trpc4 antagonist.
22 . The method of claim 14 , wherein said compound functions as a Trpc4 agonist.
23 . The method of any of claims 13 to 22 , wherein the pain is selected from the group consisting of acute, chronic, neuropathic, nociceptive, visceral, and a combination thereof.
24 . The method of claim 13 , wherein the pain comprises visceral pain.
25 . The method of claim 13 wherein the pain comprises neuropathic pain.
26 . The method of any of claims 13 to 25 , wherein said composition further comprises a second pharmaceutically active agent.
27 . The method of any of claims 13 to 26 , wherein said composition further comprises one or more additional pharmaceutically active agents selected from non-opioid analgesics, opioid analgesics, anti-epileptics, NMDA antagonists, lidocaine, tricyclic antidepressants, or a combination thereof.
28 . The method of any of claims 13 to 27 wherein said compound is administered orally.
29 . The method of any of claims 13 to 27 wherein said compound is administered topically.