Nutritional compositions and methods of treatment therewith
The disclosure provides nutritional compositions including a blend of amino acids and polyphenols. These nutritional compositions find use, for example, in treating and preventing EMS and laminitis in equines, as well as generally promoting animal health.
1. A method of treating or preventing equine metabolic syndrome or equine insulin dysregulation in an equine in need thereof, comprising:
administering to the equine a nutritional composition including a therapeutically effective amount of leucine and resveratrol.
2. The method of claim 1 , wherein the nutritional composition is orally administered to the equine in an amount of from 5 g to 150 g per day.
3. The method of claim 1 , wherein the nutritional composition is administered as a supplement mixed with equine feed.
4. A method of promoting health of an equine, comprising:
administering to the equine a nutritional composition including:
from 250 mg to 2,250 mg of resveratrol by weight of the nutritional composition;
from 700 mg to 6,300 mg of leucine by weight of the nutritional composition; and
from 580 mg to 5,220 mg of lysine by weight of the nutritional composition.
5. The method of claim 4 , wherein the promoting health comprises one or more of: promoting glycogen repletion, aiding in exercise recovery, or treating or preventing equine metabolic syndrome, insulin dysregulation, obesity, high insulin levels, pituitary pars intermedia dysfunction, altered insulin regulation, inflammation, joint disease, high blood pressure, allergies, or a glycogen storage disease.
6. The method of claim 4 , wherein the nutritional composition is administered to the equine orally on a daily dosage regimen.
7. The method of claim 1 , wherein the nutritional composition further comprises:
leucine in an amount of 0.5% to 25% of the nutritional composition by weight;
resveratrol in an amount of 0.2% to 20% of the nutritional composition by weight; and
one or more amino acids including alanine, glutamic acid, glycine, proline, or a combination thereof.
8. The method of claim 7 , wherein the resveratrol is in an amount of from 0.5% to 10% of the nutritional composition by weight.
9. The method of claim 7 , wherein the leucine is in an amount of from 1% to 15% of the nutritional composition by weight.
10. The method of claim 7 , wherein the nutritional composition further comprises lysine in an amount of from 1% to 20% of the nutritional composition by weight.
11. The method of claim 7 , wherein the nutritional composition further comprises quercetin.
12. The method of claim 7 , wherein the nutritional composition is free or substantially free of leucine metabolites.
13. The method of claim 7 , wherein the resveratrol is unencapsulated or substantially free of a carrier.
14. The method of claim 7 , wherein the nutritional composition further comprises:
4%-8% lysine of the nutritional composition by weight; and
1%-2% quercetin of the nutritional composition by weight,
wherein the resveratrol is in an amount of 1-3% of the nutritional composition by weight, and wherein the leucine is in an amount of from 3%-10% of the nutritional composition.
15. The method of claim 4 , wherein the resveratrol is from 500 mg to 1,000 mg by weight of the nutritional composition.
16. The method of claim 4 , wherein the leucine is from 1,500 mg to 2,700 mg by weight of the nutritional composition.
17. The method of claim 4 , wherein the nutritional composition further comprises quercetin.
18. The method of claim 4 , wherein the nutritional composition is free or substantially free of leucine metabolites.
19. The method of claim 4 , wherein the resveratrol is unencapsulated or substantially free of a carrier.
20. The method of claim 4 , wherein the nutritional composition comprises one or more amino acids including alanine, glutamic acid, glycine, proline, or a combination thereof.