Compositions and methods for the treatment of cellulite
Described herein are methods and formulations for treating, inhibiting, or ameliorating cellulite. Aspects described herein relate to formulations including a saline solution, reactive oxygen species, a rheology agent, an emollient, and a pH modifier and methods of using these formulations for treating, ameliorating, or inhibiting cellulite.
1. A method of reducing an appearance of cellulite in a subject in need thereof, the method comprising:
identifying a region of a body having cellulite;
topically applying to the region of the body a composition comprising:
an electrolyzed saline solution comprising a salt;
a reactive oxygen species comprising hypochlorite;
a rheology agent;
dimethicone in an amount of about 0.5% to about 10% w/v; and
a pH modifier,
wherein the salt is Himalayan sea salt present in an amount of about 0.01% to about 15% w/v, and the hypochlorite is in an amount of about 60 to about 100 ppm, and
wherein the composition has an osmolality measurement ranging from about 3 to about 5 mOsm/kg; and
massaging the composition into the region of the body having cellulite until absorbed,
thereby reducing the appearance of cellulite.
2. The method of claim 1 , wherein reducing the appearance of cellulite comprises increasing skin elasticity.
3. The method of claim 1 , wherein reducing the appearance of cellulite comprises reducing subcutaneous fat nodularity.
4. The method of claim 1 , wherein reducing the appearance of cellulite comprises increasing lipolysis in adipocytes.
5. The method of claim 1 , wherein the composition comprises:
salt in an amount of about 0.01% to about 1% w/v;
hypochlorite in an amount of about 60 to about 80 ppm;
sodium magnesium silicate in an amount of about 0.5% to about 10% w/v;
dimethicone in an amount of about 0.5% to about 10% w/v; and
sodium phosphate monobasic in an amount of about 0.05% to about 5% w/v.
6. The method of claim 5 , wherein the salt is raw, unprocessed salt.
7. The method of claim 1 , wherein the reactive oxygen species is hypochlorite present in an amount of about 65 to about 75 ppm.
8. The method of claim 1 , wherein the pH modifier is sodium phosphate monobasic present in an amount of about 0.05% to about 5% w/v.
9. The method of claim 1 , wherein the rheology agent is a metal silicate.
10. The composition of claim 9 , wherein the metal silicate is sodium magnesium silicate present in an amount of about 0.5% to about 10% w/v.
11. The method of claim 1 , wherein the composition is administered daily to the region of the body having cellulite.
12. The method of claim 1 , wherein the salt is present in an amount of about 0.05% w/v.
13. The method of claim 1 , wherein the hypochlorite is present in an amount of about 72 ppm.
14. The method of claim 1 , wherein the rheology agent is present in an amount of about 3.25% w/v.
15. The method of claim 1 , wherein the emollient is present in an amount of about 5% w/v.
16. The method of claim 1 , wherein the pH modifier is present in an amount of about 0.3% w/v.
17. The method of claim 1 , wherein the composition is formulated as a cream, foam, gel, serum, lotion, mousse, ointment, paste, solution, spray, stick, or suspension.