Residence structures and related methods
Certain embodiments comprise administering a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance, and, optionally, a linker. In some such embodiments, the linker may be configured to degrade.
1. An article, comprising:
a containing structure; and
a gastric residence structure contained within the containing structure, the residence structure comprising at least three loadable polymeric arms and a second polymeric component coupled to the loadable polymeric arms by at least one degradable linker,
wherein at least one loadable polymeric arm comprises an active substance, and the second component is free of active substance,
wherein the residence structure is constructed and arranged to have a first configuration when constrained by the containing structure, and configured to mediate a change in shape upon release from the containing structure in the stomach to assume a second configuration, the residence structure being retained in the stomach and unable, in the second configuration, to pass through the gastric pyloric orifice of the subject under gastrointestinal physiological conditions.
2. An article as in claim 1 , wherein the active substance is a therapeutic agent or a diagnostic agent.
3. An article as in claim 1 , wherein the gastric residence structure has a folding force of at least about 0.2 N.
4. An article as in claim 1 , wherein the residence structure has an open cross-sectional dimension in its second configuration of at least about 2 cm.
5. An article as in claim 1 , wherein the loadable polymeric component comprises at least 10 wt. % active substance of the total weight of the loadable polymeric component.
6. An article as in claim 1 , wherein the residence structure comprises a polymeric material configured for bending at one or more vertices.
7. An article as in claim 1 , wherein the residence structure is retained in the stomach for at least about 1 week.
8. An article as in claim 1 , wherein the active substance is configured to be released at a rate of at least about 1% of the initial average rate on the fifth day of release.
9. An article as in claim 1 , wherein the residence structure in its second configuration has a cross-sectional dimension of at least about 2 cm.
10. An article as in claim 1 , wherein at least one of the loadable polymeric component, the second polymeric component, and the degradable linker comprises an elastic polymeric component.
11. An article as in claim 10 ,
wherein the residence structure can be retained in the stomach for at least about 48 hours in the second configuration,
wherein the loadable polymeric component is configured to release the active substance within the stomach for at least about 48 hours, at a particular initial average rate as determined over the first 24 hours of release and at an average rate of at least about 1% of the initial average rate over a second 24 hour period after the first 24 hours of release,
wherein the separate degradable component, after at least about 48 hours, degrades, dissolves, disassociates, and/or mechanically weakens in the gastric environment under gastrointestinal physiological conditions which results in loss of retention of the second configuration and passage of the residence structure out of the stomach through the gastric pyloric orifice.
12. An article as in claim 10 , wherein the residence structure in its second configuration has a multi-armed star shape.
13. An article, comprising:
a containing structure; and
a gastric residence structure contained within the containing structure, the residence structure comprising multiple interconnected components including at least a plurality of loadable polymeric components, one or more second polymeric components, and at least a plurality of degradable linkers,
wherein the degradable linkers interconnect the plurality of loadable polymeric components and the one or more second polymeric components,
wherein the plurality of loadable polymeric components comprise an active substance, and the one or more second polymeric components are free of active substance,
wherein the residence structure is constructed and arranged to have a first configuration when constrained by the containing structure, and configured to mediate a change in shape upon release from the containing structure in the stomach to assume a second configuration, the residence structure being retained in the stomach and unable, in the second configuration, to pass through the gastric pyloric orifice of the subject under gastrointestinal physiological conditions.