OXYMETAZOLINE FOR THE TREATMENT OF ANO-RECTAL DISORDERS
Methods for treating fecal incontinence by administering to a subject in need thereof compositions including oxymetazoline as an active ingredient. Kits including compositions of oxymetazoline suitable for topical application, for the treatment of fecal incontinence.
1 . A method,
wherein the method treats fecal incontinence in a subject in need thereof,
wherein the method comprises: administering a therapeutically effective amount of a composition comprising oxymetazoline or a pharmaceutically acceptable salt thereof to the subject's anal cavity, to treat the fecal incontinence,
wherein the therapeutically effective amount of the composition comprises 0.1% to 1% of oxymetazoline or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , wherein the composition comprises oxymetazoline hydrochloride.
3 . The method of claim 1 , wherein the composition further comprises at least one carrier, diluent, excipient, or combinations thereof.
4 . The method of claim 1 , wherein the composition is selected from the group consisting of: long acting, controlled release, slow release, sustained release, bioadhesive and mucoadhesive.
5 . The method of claim 1 , wherein the composition is in a dosage form selected from the group consisting of: gel, cream, paste, spray suppository, mousse, emollient, powder, solution, suspension and foam.
6 . The method of claim 1 , wherein the therapeutically effective amount of the composition comprises 0.08% to 0.8% of oxymetazoline or a pharmaceutically acceptable salt thereof.
7 . The method of claim 1 , wherein the therapeutically effective amount of the composition comprising oxymetazoline or a pharmaceutically acceptable salt thereof is sufficient to treat fecal incontinence in the subject for at least 4 hours.