Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.
1. A contact lens; comprising:
a) a first surface and a second surface; and
b) said contact lens further comprising at least one coating provided on at least a portion of said first surface, said second surface, or a combination thereof as opposed to within said contact lens;
1) said coating comprising at least one three dimensional structure; and
2) said three dimensional structure comprising:
a. one or more drug reservoir layers;
wherein said one or more drug reservoir layers comprise one or more drugs comprising HA; and
b. one or more barrier layers;
wherein said one or more barrier modulates the release of said one or more drugs from said drug delivery contact lens;
wherein said HA acts as a comfort enhancing agent or comfort enhancing drug; and
further wherein said HA can be released from said contact lens when operably engaged with the surface of the eye of a subject.
2. The contact lens of claim 1 ,
wherein said coating comprising one or more drugs comprising HA is provided at least in part by inkjet printing.
3. The contact lens of claim 1 ,
wherein the molecular weight of said HA is:
a) from between about 5,000 Dalton and about 4 million Daltons;
b) from between about 10,000 Daltons and about 2 million Daltons,
c) from between about 20,000 Daltons and about 1 million Daltons,
d) from between about 50,000 Daltons and about 500,000Daltons, or
e) a combination thereof.
4. The contact lens of claim 1 ,
further wherein bulk density of said HA is:
a) from between about 0.03 g/ml and about 0.15 g/ml;
b) from between about 0.05 g/ml and about 0.15 g/ml; or
c) a combination thereof.
5. The contact lens of claim 1 ,
further wherein the Concentration of HA in said coating is between about 0.01% and about 5.0%.
6. The contact lens of claim 1 ,
wherein said contact lens is steam sterilized.
7. The contact lens of claim 1 ,
further wherein said contact lens is in packaging solution with:
a) from between about 0.01% and about 5% HA;
b) from between about 0.1% and about 3% HA;
c) from between about 1% and about 2% HA; or
d) a combination thereof.
8. The contact leans of claim 1 ,
further wherein said contact lens is in a packaging solution having a pH between about 6.5 and about 7.8.
9. The contact leans of claim 1 ,
further wherein said HA can be released up to:
a) from between about 1 hours to up to about 45 days;
b) from between about 10 hours and about 20 days;
c) from between about 20 hours and about 10 days;
d) from between about 40 hours and about 7 days; or
e) a combination thereof.
10. The contact lens of claim 1 ,
wherein said HA is loaded in an ink used to make said contact lens using microemulsion, micelles, encapsulation, nanoparticle, spray drying, in solvent, microspheres, liposomes, ethosomes, niosomes, biodegradable nanoparticles, temperature sensitive smart particles, or combination thereof.
11. The contact lens of claim 10 ,
further wherein said HA is incorporated into a polymer matrix as a spray dried particle of size:
a) from less than about 1 microns and about 50 microns in diameter;
b) from between about 2 microns and about 20 microns in diameter;
c) from between about 5 microns and about 10 microns in diameter; or
d) a combination thereof.