IP Library › Granted Patent US 11,167,010
Granted Patent B2
US 11,167,010 · App. 16/189,868 · Granted Nov 9, 2021

Trefoil family factor proteins and uses thereof

Inventors: Timothy C. Wang (New York, NY); Jan K. Kitajewski (Ridgewood, NJ)
Assignee: The Trustees of Columbia University in the City of New York
A61K38/1709A61K38/22G01N33/57419G01N33/57446G01N2333/4704
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,167,010
App. No.
16/189,868
Granted
Nov 9, 2021
Kind
B2
Abstract

The invention provides for methods for treating an inflammatory disease of the digestive system in a subject by administering a trefoil family molecule. The invention provides for methods for treating a digestive system cancer in a subject by administering a trefoil family molecule. The invention provides for methods for cell proliferation in a subject by administering a trefoil family molecule.

Claims (5)

1. An isolated polypeptide comprising a carboxy-terminal peptide (CTP) domain fused to a TFF2 protein, wherein the CTP domain comprises the C-terminal domain of the beta subunit of the human chorionic gonadotrophin (hCG).

2. The isolated polypeptide of claim 1 wherein one CTP domain is fused to the C-terminus of the TFF2 protein.

3. The isolated polypeptide of claim 1 wherein two CTP domains are fused in tandem to the C-terminus of the TFF2 protein.

4. The isolated polypeptide of claim 1 wherein three CTP domains are fused in tandem to the C-terminus of the TFF2 protein.

5. A pharmaceutical composition comprising the isolated polypeptide of claim 1 and a pharmaceutically acceptable carrier.

Assignments (3)
CONFIRMATORY LICENSE Recorded Nov 4, 2022
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 061883/0567 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 17, 2019
From: WANG, TIMOTHY C.; KITAJEWSKI, JAN K.
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 050401/0572 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2019
From: WANG, TIMOTHY C.; KITAJEWSKI, JAN K.
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 050134/0786 →
Continuity (5)
Continuation 15367958 · Dec 2, 2016
Continuation 14550246 · Nov 21, 2014
Continuation In Part PCTUS2013034981 · Apr 2, 2013
Provisional Application 61649767 · May 21, 2012
Related Publication 20190298798A1 · Oct 3, 2019