Method for preventing or treating heart failure by administering a medicament containing an antagonist of corticotropin releasing hormone receptor 2 (CRHR2)
A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient.
1. A method for preventing or treating heart failure by inhibiting a corticotropin releasing hormone receptor 2-mediated intracellular signal transduction, comprising the following steps:
(1) selecting a subject whose value of urocortin 2 is higher than a reference value, and
(2) administering to the subject an effective amount of a medicament containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient,
wherein the antagonist of the corticotropin releasing hormone receptor 2 is selected from the group consisting of cyclohexyl amide derivatives and antisauvagine-30.