IP Library Granted Patent US 11,135,270
Granted Patent B2
US 11,135,270 · App. 16/198,937 · Granted Oct 5, 2021

Method for preventing or treating heart failure by administering a medicament containing an antagonist of corticotropin releasing hormone receptor 2 (CRHR2)

Inventor: Mikito Takefuji (Aichi, JP)
Assignee: RAQUALIA PHARMA INC.
A61K38/2228A61K31/167A61K38/16A61P9/04G01N33/74C07K14/001C07K14/575C07K14/57509C07K14/72G01N2333/726G01N2500/02G01N2800/325
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Quick Facts
Patent No.
US 11,135,270
App. No.
16/198,937
Granted
Oct 5, 2021
Kind
B2
Abstract

A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient.

Claims (4)

1. A method for preventing or treating heart failure by inhibiting a corticotropin releasing hormone receptor 2-mediated intracellular signal transduction, comprising the following steps:

(1) selecting a subject whose value of urocortin 2 is higher than a reference value, and

(2) administering to the subject an effective amount of a medicament containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient,

wherein the antagonist of the corticotropin releasing hormone receptor 2 is selected from the group consisting of cyclohexyl amide derivatives and antisauvagine-30.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2021
From: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
To: RAQUALIA PHARMA INC.
Reel/Frame 057171/0765 →
CHANGE OF NAME Recorded Jul 21, 2021
From: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
To: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
Reel/Frame 056988/0399 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 23, 2018
From: TAKEFUJI, MIKITO
To: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
Reel/Frame 047568/0133 →
Priority Claims (1)
JP JP2017-226046 · Nov 24, 2017 · national
Continuity (1)
Related Publication 20190160151A1 · May 30, 2019