Granted Patent
B2
US 10,800,827 · App. 16/199,774 · Granted Oct 13, 2020
Insulin receptor partial agonists
Inventors:
Songnian Lin (Holmdel, NJ); Lin Yan (East Brunswick, NJ); Pei Huo (Millburn, NJ); Dmitri Pissarnitski (Scotch Plains, NJ); Danqing Feng (Green Brook, NJ); Ravi Nargund (East Brunswick, NJ); Yuping Zhu (Edison, NJ); Ahmet Kekec (Hoboken, NJ); Christina B. Madsen-Duggan (Scotch Plains, NJ); Zhi-Cai Shi (Monmouth Junction, NJ); Zhicai Wu (Kenilworth, NJ); Yingjun Mu (Kenilworth, NJ)
Assignee:
MERCK SHARP & DOHME CORP.
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
Claims (4)
1. An insulin receptor partial agonist comprising: a compound selected from the group consisting of:
2. A composition comprising one or more of the insulin receptor partial agonist of claim 1 and a pharmaceutically acceptable carrier.
3. A method for treating diabetes comprising administering to an individual with diabetes a therapeutically effective amount of a composition comprising the insulin receptor partial agonist of claim 1 .
4. The method of claim 3 , wherein the diabetes is Type 1 diabetes, Type 2 diabetes, or gestational diabetes.
Assignments (2)
MERGER
Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 26, 2018
From: LIN, SONGNIAN; YAN, LIN; HUO, PEI; PISSARNITSKI, DMITRI; FENG, DANQING; NARGUND, RAVI; ZHU, YUPING; KEKEC, AHMET; MADSEN-DUGGAN, CHRISTINA B.; SHI, ZHI-CAI; WU, ZHICAI; MU, YINGJUN
To: MERCK SHARP & DOHME CORP.
Reel/Frame 047582/0083 →
Continuity (5)
Provisional Application
62242503
· Oct 16, 2015
Provisional Application
62082857
· Nov 21, 2014