IP Library › Granted Patent US 10,772,970
Granted Patent B2
US 10,772,970 · App. 16/204,825 · Granted Sep 15, 2020

Glucocorticoid receptor agonist and immunoconjugates thereof

Inventors: Adrian Hobson (Shrewsbury, MA); Michael McPherson (Ashby, MA); Wendy Waegell (Brookfield, MA); Christian Goess (Sturbridge, MA); Axel Hernandez, Jr. (Charlton, MA); Lu Wang (Northborough, MA); Lu Wang (Westborough, MA); Christopher C. Marvin (Grayslake, IL); Ling C. Santora (Shrewsbury, MA)
Assignee: AbbVie Inc.
A61K47/6803A61K38/191A61K47/6845A61K47/6889A61P1/00A61P19/02C07K16/241C07K16/249C07K2317/21C07K2317/76
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Quick Facts
Patent No.
US 10,772,970
App. No.
16/204,825
Granted
Sep 15, 2020
Kind
B2
Abstract

Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.

Claims (12)

1. An antibody drug conjugate comprising:

(a) an anti-TNFα antibody comprising a heavy chain set forth as SEQ ID NO: 3 and a light chain set forth as SEQ ID NO: 4; and

(b) a glucocorticoid receptor agonist comprising a radical represented by the formula:

wherein the antibody is conjugated to the glucocorticoid receptor agonist via a linker represented by the formula:

2. The antibody drug conjugate of claim 1 , according to the formula:

wherein A is the antibody and n is an integer from 1-10.

3. The antibody drug conjugate of claim 2 , wherein n is 4.

4. The antibody drug conjugate of claim 2 , wherein n is 2.

5. An antibody drug conjugate according to the formula:

wherein A is adalimumab and n is 4.

6. An antibody drug conjugate according to the formula:

wherein A is adalimumab and n is 2.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2019
From: HOBSON, ADRIAN; MCPHERSON, MICHAEL; WAEGELL, WENDY; GOESS, CHRISTIAN; HERNANDEZ, JR., AXEL; WANG, LU, MS.; WANG, LU; MARVIN, CHRISTOPHER C.; SANTORA, LING C.
To: ABBVIE INC.
Reel/Frame 048940/0939 →
Continuity (3)
Provisional Application 62593776 · Dec 1, 2017
Provisional Application 62595054 · Dec 5, 2017
Related Publication 20190167804A1 · Jun 6, 2019