IP Library Granted Patent US 10,448,658
Granted Patent B2
US 10,448,658 · App. 16/207,811 · Granted Oct 22, 2019

Cow food and methods of husbandry for increased milk production

Inventors: Mallory Embree (San Diego, CA); Luke Picking (San Diego, CA); Grant Gogul (Cardiff, CA); Janna Tarasova (San Diego, CA)
Assignee: Ascus Biosciences, Inc.
A23K10/18A23K10/30A23K10/37A23K20/158A23K20/163A23K20/28A23K40/35A23K50/10A23L31/10A23L33/135A61K9/0019A61K9/0053A61K35/74A61K35/741A61K35/742A61K36/06A61K36/064A61K39/02A61P31/04C12N1/14C12N1/20
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,448,658
App. No.
16/207,811
Granted
Oct 22, 2019
Kind
B2
Abstract

The disclosure relates to animal food and methods for shifting rumen microbiome in a ruminant animal, such as a cow. Particularly, the disclosure provides a cow food comprising microorganisms, such as a Pichia sp. and a Clostridium sp.

Claims (26)

1. A method of shifting the rumen microbiome of a cow, comprising:

feeding the cow a food comprising a Pichia kudriavzevii and a Clostridium butyricum ,

wherein a first population of microbes present in the rumen of the cow before feeding the food increase in abundance after feeding the food; and

wherein a second population of microbes present in the rumen of the cow before feeding the food decrease in abundance after feeding the food.

2. The method of claim 1 , wherein the food comprises cereals, starches, oilseed cakes, or vegetable wastes.

3. The method of claim 1 , wherein the food is solid, liquid, or a mixture thereof.

4. The method of claim 1 , wherein the food comprises a thickening agent.

5. The method of claim 4 , wherein the thickening agent is selected from the group consisting of silica, clay, natural extracts of seeds or seaweed, synthetic derivatives of cellulose, guar gum, locust bean gum, alginates, and methylcelluloses.

6. The method of claim 1 , wherein the food comprises an anti-settling agent.

7. The method of claim 6 , wherein the anti-settling agent is selected from the group consisting of modified starches, polyvinyl alcohol, and xanthan gum.

8. The method of claim 1 , wherein the food comprises a fat or an oil.

9. The method of claim 8 , wherein the fat is an animal fat or a vegetable fat, and the oil is an animal oil or a vegetable oil.

10. The method of claim 1 , wherein the food comprises an acceptable carrier.

11. The method of claim 10 , wherein the acceptable carrier is selected from the group consisting of edible feed grade material, mineral mixture, water, glycol, molasses, and corn oil.

12. The method of claim 1 , wherein the food is mixed with livestock feed, forage, fodder, beans, grains, micro-ingredients, fermentation compositions, or a mixture thereof.

13. The method of claim 1 , wherein the food is fed to the cow at least once per day.

14. The method of claim 1 , wherein the food is fed to the cow in combination with water, medicine, vaccination, or a mixture thereof.

15. The method of claim 1 , wherein the Pichia kudriavzevii and the Clostridium butyricum in the food are in the form of spores, vegetative cells, or lysed cells.

16. The method of claim 15 , wherein the spores germinate upon feeding the food to the cow.

17. The method of claim 1 , wherein the food is in the form of pellets, capsules, granulated, powdered, liquid, or semi-liquid.

18. The method of claim 1 , wherein the shifting of the rumen microbiome in the cow leads to one or more desired phenotypes or improved traits in the cow.

19. The method of claim 18 , wherein the desired phenotype or improved trait is selected from the group consisting of an improved efficiency in feed utilization, improved digestibility, an increase in polysaccharide and lignin degradation, an increase in fatty acid concentration in the rumen, pH balance in the rumen, a reduction in methane emissions, a reduction in manure production, improved dry matter intake, an improved efficiency of nitrogen utilization, or combinations thereof, compared to a cow that has not been fed with the food.

20. The method of claim 1 , wherein the shifting of the rumen microbiome in the cow leads to change of production of volatile fatty acids and/or digestibility of feed in the cow, compared to a cow that has not been fed with the food.

21. The method of claim 1 , wherein the shifting of the rumen microbiome in the cow leads to altered carbohydrate content of milk produced by the cow, compared to a cow that has not been fed with the food.

22. The method of claim 1 , wherein the shifting of the rumen microbiome in the cow leads to an increase in milk production and/or milk components compared to a cow that has not been fed with the food.

23. The method of claim 1 , wherein the shifting of the rumen microbiome in the cow leads to an improved milk compositional characteristic selected from the group consisting of: an increase in milk fat(s), an increase in milk protein(s), an increase of carbohydrates in milk, an increase of vitamins in milk, an increase of minerals in milk, and combinations thereof.

Assignments (3)
SECURITY INTEREST Recorded Jul 30, 2025
From: NATIVE MICROBIALS, INC.
To: WESTERN ALLIANCE BANK
Reel/Frame 072324/0001 →
CHANGE OF NAME Recorded Sep 9, 2020
From: ASCUS BIOSCIENCES, INC.
To: NATIVE MICROBIALS, INC.
Reel/Frame 053732/0496 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2019
From: EMBREE, MALLORY; PICKING, LUKE; GOGUL, GRANT; TARASOVA, JANNA
To: ASCUS BIOSCIENCES, INC.
Reel/Frame 048137/0791 →
Continuity (7)
Continuation 16029398 · Jul 6, 2018
Continuation PCTUS2017012573 · Jan 6, 2017
Provisional Application 62415908 · Nov 1, 2016
Provisional Application 62334816 · May 11, 2016
Provisional Application 62276142 · Jan 7, 2016
Provisional Application 62276531 · Jan 8, 2016
Related Publication 20190200642A1 · Jul 4, 2019