Debriding wound dressing, process of manufacture and useful articles thereof
A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies, includes an active ingredient, such as collagenase, which serves to debride wounds in-situ. In one example, purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.
1. A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds, comprising
a substrate, the substrate having a non-adherent wound contacting layer having a wound contacting side, the non-adherent wound contacting layer comprising only silicone,
the wound dressing having a wound contacting surface, the wound contacting side of the non-adherent wound contacting layer comprising the entire wound contacting surface of the wound dressing, and
a coating of an effective amount of an enzymatic debriding agent on and being in direct contact with the wound contacting side of the non-adherent wound contacting layer,
the enzymatic debriding agent being collagenase, and
the collagenase being 90% pure collagenase, and the collagenase on the wound contacting side of the non-adherent wound contacting layer having a coating weight of 1.31 mg/square centimeter.
2. The wound dressing of claim 1 ,
the substrate comprising a polyester non-woven mesh coated with silicone on one side, and
the silicone comprising the non-adherent wound contacting layer.
3. The wound dressing of claim 1 ,
the substrate comprising a polyester non-woven mesh coated on both sides with silicone, and
the silicone on either side of the polyester non-woven mesh comprising the non-adherent wound contacting layer.
4. A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds, comprising
a substrate, the substrate having a non-adherent wound contacting layer having a wound contacting side, the non-adherent wound contacting layer comprising only silicone,
the wound dressing having a wound contacting surface, the wound contacting side of the non-adherent wound contacting layer comprising the entire wound contacting surface of the wound dressing, and
a dusting of an effective amount of an enzymatic debriding agent on and being in direct contact with the wound contacting side of the non-adherent wound contacting layer,
the enzymatic debriding agent being collagenase, and
the collagenase being 90% pure collagenase, and the collagenase on the wound contacting side of the non-adherent wound contacting layer having a coating weight of 1.31 mg/square centimeter.
5. The wound dressing of claim 4 ,
the substrate comprising a polyester non-woven mesh coated with silicone on one side, and
the silicone comprising the non-adherent wound contacting layer.
6. The wound dressing of claim 4 ,
the substrate comprising a polyester non-woven mesh coated on both sides with silicone, and
the silicone on either side of the polyester non-woven mesh comprising the non-adherent wound contacting layer.
7. A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds, comprising
a substrate, the substrate having a wound contacting surface, and the wound contacting surface of the substrate comprising only silicone, and
a dusting on the wound contacting surface of the substrate of an effective amount of an enzymatic debriding agent, and
the enzymatic debriding agent being collagenase,
wherein the collagenase is 90% pure collagenase, and wherein the collagenase on the substrate has a coating weight of 1.31 mg/square centimeter.
8. The wound dressing of claim 7 ,
the substrate comprising a polyester non-woven mesh coated with silicone on one side.
9. The wound dressing of claim 7 ,
the substrate comprising a polyester non-woven mesh coated on both sides with silicone.
10. A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds, comprising
a substrate, the substrate having a wound contacting surface, and the wound contacting surface of the substrate comprising only silicone, and
a coating on the wound contacting surface of the substrate of an effective amount of an enzymatic debriding agent, and
the enzymatic debriding agent being collagenase,
wherein the collagenase is 90% pure collagenase, and wherein the collagenase on the substrate has a coating weight of 1.31 mg/square centimeter.
11. The wound dressing of claim 10 ,
the substrate comprising a polyester non-woven mesh coated with silicone on one side.
12. The wound dressing of claim 10 ,
the substrate comprising a polyester non-woven mesh coated on both sides with silicone.
13. A wound dressing for active continuous debridement of devitalized tissues in non-healing wounds, comprising
a non-adherent wound contacting layer having a wound contacting side,
the non-adherent wound contacting layer comprising only silicone, and
the wound contacting side of the non-adherent wound contacting layer having an effective amount of an enzymatic debriding agent on and in direct contact with the wound contacting side of the non-adherent wound contacting layer,
the enzymatic debriding agent being collagenase,
the collagenase being 90% pure collagenase, and the collagenase on the wound contacting side of the non-adherent wound contacting layer having a coating weight of 1.31 mg/square centimeter.