N-amino peptide beta-sheet mimics for the treatment of Alzheimer's disease
Disclosed herein are compounds comprising short N-aminated peptides and compositions comprising the same. The disclosed compounds and compositions maybe used in methods of inhibiting amyloid-beta aggregation and treating Alzheimer's disease.
1. A compound of formula (I),
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are each independently selected from hydrogen or —NH 2 , and wherein at least one of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is —NH 2 .
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein two of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are —NH 2 .
3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 3 are —NH 2 .
4. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 5 are —NH 2 .
5. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 2 and R 4 are —NH 2 .
6. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 2 and R 6 are —NH 2 .
7. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 3 and R 5 are —NH 2 .
8. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 4 and R 6 are —NH 2 .
9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein three of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are —NH 2 .
10. The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein R 1 , R 3 and R 5 are —NH 2 .
11. The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein R 2 , R 4 and R 6 are —NH 2 .
12. A pharmaceutical composition comprising an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
13. A method of inhibiting amyloid-beta aggregation in a subject, comprising administering to the subject an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition of claim 12 .
14. A method of treating a Alzheimer's disease in a subject, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition of claim 12 .