High-resolution mapping of tissue with pacing
According to some embodiments, a method of confirming successful ablation of targeted cardiac tissue of a subject using a high-resolution mapping electrode comprises pacing said cardiac tissue at a predetermined pacing level to increase the heart rate of the subject from a baseline level to an elevated level, the predetermined pacing level being greater than a pre-ablation pacing threshold level but lower than a post-ablation pacing threshold level, delivering ablative energy to the ablation electrode, detecting the heart rate of the subject, wherein the heart rate detected by the high-resolution mapping electrode is at the elevated level before the post-ablation pacing threshold level is achieved, and wherein the heart rate detected by the high-resolution mapping electrode drops below the elevated level once ablation achieves its therapeutic goal or target, and terminating the delivery of ablative energy to the ablation electrode after the heart rate drops below the elevated level.
1. An energy delivery module configured to deliver ablative energy to targeted cardiac tissue of a subject and for confirming successful ablation of said targeted cardiac tissue, comprising:
a processor for regulating the delivery of ablative energy;
wherein the energy delivery module is configured to operatively couple to a catheter, wherein the energy delivery module is configured to energize a high-resolution electrode positioned along a distal end of the catheter to selectively ablate said targeted cardiac tissue adjacent the high-resolution electrode;
wherein the processor is configured, via a predetermined pacing signal provided to the catheter by a pacemaker, to increase the heart rate of the subject from a baseline level to an elevated level, the predetermined pacing signal comprising a pacing level greater than a pre-ablation pacing threshold level; and
wherein the processor is configured to terminate the delivery of ablative energy to the high-resolution electrode after loss of capture of the heart of the subject,
wherein the high-resolution electrode comprises a distal portion and a proximal portion, wherein the distal and proximal portions function as a single electrode when the ablative energy is delivered by the high-resolution electrode to the targeted cardiac tissue; and wherein the distal and proximal portions of the high-resolution electrode are operatively coupled to each other using at least one filtering element.
2. The energy delivery module of claim 1 , further comprising the pacemaker, wherein the pacemaker is integrated within the energy delivery module.
3. The energy delivery module of claim 1 , further comprising the pacemaker.
4. The energy delivery module of claim 1 , wherein the pacemaker is integrated within the energy delivery module.
5. The energy delivery module of claim 1 , wherein the pacemaker is separate from the energy delivery module.
6. A kit for delivering ablative energy to targeted cardiac tissue of a subject and for confirming successful ablation of said targeted cardiac tissue, comprising:
a catheter comprising a high-resolution electrode along a distal end of the catheter; and
an energy delivery module comprising a processor, wherein the processor is configured to regulate the delivery of ablative energy;
wherein the energy delivery module is configured to operatively couple to the catheter, wherein the energy delivery module is configured to energize the high-resolution electrode positioned along a distal end of the catheter to selectively ablate said targeted cardiac tissue adjacent the high-resolution electrode;
wherein the processor is configured, via a predetermined pacing signal provided to the catheter by a pacemaker, to increase the heart rate of the subject from a baseline level to an elevated level, the predetermined pacing signal comprising a pacing level greater than a pre-ablation pacing threshold level; and
wherein the processor is configured to terminate the delivery of ablative energy to the high-resolution electrode after loss of capture of the heart of the subject,
wherein the high-resolution electrode comprises a distal portion and a proximal portion, wherein the distal and proximal portions function as a single electrode when the ablative energy is delivered by the high-resolution electrode to the targeted cardiac tissue; and wherein the distal and proximal portions of the high-resolution electrode are operatively coupled to each other using at least one filtering element.
7. The kit of claim 6 , further comprising the pacemaker, wherein the pacemaker is separate from the energy delivery module.
8. The kit of claim 6 , further comprising the pacemaker.
9. The kit of claim 6 , wherein the pacemaker is integrated within the energy delivery module.
10. The kit of claim 6 , wherein the pacemaker is separate from the energy delivery module.
11. A generator configured to deliver ablative energy to targeted cardiac tissue of a subject and for confirming successful ablation of said targeted cardiac tissue, comprising:
an energy delivery module configured to generate ablative energy for delivery to an ablation device; and
a processor configured to regulate the delivery of ablative energy from the energy delivery module to a high-resolution electrode of the ablation device;
wherein ablative energy generated by the energy delivery module is delivered to the high-resolution electrode;
wherein the processor is configured, via a predetermined pacing signal provided to the high-resolution electrode by a pacemaker, to increase the heart rate of the subject from a baseline level to an elevated level, the predetermined pacing signal comprising a pacing level greater than a pre-ablation pacing threshold level; and
wherein the processor is configured to terminate the delivery of energy to the high-resolution electrode after loss of capture of the heart of the subject,
wherein the high-resolution electrode comprises a distal portion and a proximal portion, wherein the distal and proximal portions function as a single electrode when the ablative energy is delivered by the high-resolution electrode to the targeted cardiac tissue; and wherein the distal and proximal portions of the high-resolution electrode are operatively coupled to each other using at least one filtering element.
12. The generator of claim 11 , wherein the energy delivery module is configured to generate radiofrequency (RF) energy.
13. The generator of claim 11 , wherein the processor and the energy delivery module are located within a single housing or enclosure.
14. The generator of claim 11 , wherein the processor and the energy delivery module are located within separate housings or enclosures.
15. The generator of claim 11 , further comprising the pacemaker.
16. The generator of claim 15 , wherein the pacemaker is integral to the energy delivery module.
17. The generator of claim 15 , wherein the pacemaker is separate from the energy delivery module.
18. The generator of claim 11 , wherein the at least one filtering element comprises a capacitor.