Piperidine-substituted Mnk inhibitors and methods related thereto
The present invention relates to compounds according to Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof wherein X 1 , X 2 , R 1 , R 2 , R 3 and n are as defined herein. Also described are pharmaceutically acceptable compositions of Formula (I) compounds as well as methods for utilizing the compounds of Formula (I) and the pharmaceutically acceptable compositions of Formula (I) compounds as inhibitors of Mnk as well as therapeutics for the treatment of diseases such as cancer.
1. A compound having the structure
or a pharmaceutically acceptable salt thereof.
2. A compound having the structure
or a pharmaceutically acceptable salt thereof.
3. A compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.