IP Library › Patent Application 16241316
Patent Application
App. No. 16/241,316

ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF

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Quick Facts
Patent No.
US None
App. No.
16/241,316
Abstract

The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.

Claims (20)

1 . A method of treating a microbial infection, comprising:

administering to a subject in need thereof an effective amount of an antimicrobial peptide comprising a first antimicrobial domain comprising at least two VGVSV (SEQ ID NO:2) motifs.

2 . The method of claim 1 , wherein said antimicrobial peptide has a length of 10-200 amino acids.

3 . (canceled)

4 . The method of claim 1 , wherein said antimicrobial peptide comprises at least one VGVSV motif at the N-terminal.

5 . The method of claim 1 , wherein said antimicrobial peptide comprises at least one VGVSV motif at the C-terminal.

6 . The method of claim 1 , wherein said antimicrobial peptide comprises the amino acid sequence of VGVSVAAVGVSV (SEQ ID NO:4).

7 . The method of claim 1 , wherein said antimicrobial peptide further comprises a second antimicrobial domain, wherein said second antimicrobial domain is different from said first antimicrobial domain.

8 . The method of claim 1 , wherein said antimicrobial peptide further comprises a cell penetrating peptide (CPP) domain.

9 . The method of claim 1 , wherein said antimicrobial peptide further comprises a targeting domain.

10 . The method of claim 1 , wherein said antimicrobial peptide is administered in combination with another antimicrobial agent.

11 . The method of claim 10 , wherein said another antimicrobial agent is another antimicrobial peptide.

12 . The method of claim 10 , wherein said another antimicrobial agent is an in vivo expression vector encoding said antimicrobial peptide.

13 . The method of claim 10 , wherein said antimicrobial peptide is a PEGylated peptide.

14 - 18 . (canceled)

19 . A pharmaceutical composition for treating microbial infection, comprising:

(1) an antimicrobial peptide comprising a first antimicrobial domain comprising two VGVSV (SEQ ID NO:2) motifs, and a cell penetrating peptide (CPP) domain and/or a targeting domain; and

(2) a pharmaceutically acceptable carrier.

20 . The pharmaceutical composition of claim 19 , wherein said antimicrobial peptide is a PEGylated peptide.

21 . The pharmaceutical composition of claim 19 , wherein said antimicrobial peptide further comprises a second antimicrobial domain, wherein said second antimicrobial domain is different from said first antimicrobial domain.