IONIC POLYMER COMPOSITIONS
The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.
1 . An orthopedic implant comprising a crosslinked ionic polymer that comprises sulfonic-acid-derivatized groups.
2 . The orthopedic implant of claim 1 , wherein the sulfonic-acid-derivatized groups are amino-sulfonic-acid-derivatized groups.
3 . The orthopedic implant of claim 1 , wherein the sulfonic-acid-derivatized groups are sulfonic-acid-derivatized carboxylic groups.
4 . The orthopedic implant of claim 3 , wherein the crosslinked ionic polymer further comprises underivatized carboxylic acid groups.
5 . The orthopedic implant of claim 4 , wherein the underivatized carboxylic acid groups correspond to one or more of the following: underivatized acrylic acid polymerized monomers within the ionic polymer, underivatized methacrylic acid polymerized monomers within the ionic polymer, underivatized crotonic acid polymerized monomers within the ionic polymer, underivatized linolenic acid polymerized monomers within the ionic polymer, underivatized maleic acid polymerized monomers within the ionic polymer, and underivatized fumaric acid polymerized monomers within the ionic polymer, and wherein the amino-sulfonic-acid-derivatized carboxylic acid groups correspond one or more of amino-sulfonic-acid-derivatized acrylic acid polymerized monomers within the ionic polymer, amino-sulfonic-acid-derivatized methacrylic acid polymerized monomers within the ionic polymer, amino-sulfonic-acid-derivatized crotonic acid polymerized monomers within the ionic polymer, amino-sulfonic-acid-derivatized linolenic acid polymerized monomers within the ionic polymer, amino-sulfonic-acid-derivatized maleic acid polymerized monomers within the ionic polymer, and amino-sulfonic-acid-derivatized fumaric acid polymerized monomers within the ionic polymer.
6 . The orthopedic implant of claim 2 , wherein the implant comprises a measurable amount of an amino sulfonic acid compound of the formula (H 2 N) x R(SO 3 H) y or a salt thereof, where R is an organic moiety, x is a positive integer and y is a positive integer.
7 . The orthopedic implant of claim 6 , wherein R is a hydrocarbon moiety.
8 . The orthopedic implant of claim 7 , wherein the hydrocarbon moiety is an alkane moiety, an alkene moiety, an alkyne moiety, an aromatic moiety, or a hydrocarbon moiety having a combination of two or more of alkane, alkene, alkyne and aromatic substituents.
9 . The orthopedic implant of claim 7 , wherein the hydrocarbon moiety is a C1-C12 hydrocarbon moiety.
10 . The orthopedic implant of claim 2 , wherein the implant comprises a measurable amount of an amino sulfonic acid compound selected from taurine and taurine derivatives.
11 . The orthopedic implant of claim 4 , wherein a concentration of the underivatized carboxylic acid groups and a concentration of the sulfonic-acid-derivatized carboxylic acid groups are substantially constant throughout the implant.
12 . The orthopedic implant of claim 4 , wherein a concentration of the underivatized carboxylic acid groups and/or a concentration of the sulfonic-acid-derivatized carboxylic acid groups varies by at least +/−10% between two points in the implant.
13 . The orthopedic implant of claim 4 , wherein the implant comprises a gradient in a concentration of the underivatized carboxylic acid groups and/or a gradient in a concentration of the sulfonic-acid-derivatized carboxylic acid groups.
14 . The orthopedic implant of claim 13 , wherein a concentration of the underivatized carboxylic acid groups decreases with increasing distance from at least one outer surface of the implant or wherein a concentration of the underivatized carboxylic acid groups increases with increasing distance from at least one outer surface of the implant.
15 . The orthopedic implant of claim 13 , wherein a concentration of the amino-sulfonic-acid-derivatized carboxylic acid groups decreases with increasing distance from at least one outer surface of the implant or wherein a concentration of the amino-sulfonic-acid-derivatized carboxylic acid groups increases with increasing distance from at least one outer surface of the implant.
16 . The orthopedic implant of claim 4 , wherein a molar ratio of the sulfonic-acid-derivatized carboxylic acid groups to the underivatized carboxylic acid groups varies by at least +/−10% between two points in the implant.
17 . The orthopedic implant of claim 4 , wherein a molar ratio of the sulfonic-acid-derivatized carboxylic acid groups to the underivatized carboxylic acid groups decreases with increasing distance from at least one outer surface of the implant within the implant or wherein a molar ratio of the sulfonic-acid-derivatized carboxylic acid groups to the underivatized carboxylic acid groups increases with increasing distance from at least on outer surface of the implant within the implant.
18 . The orthopedic implant of claim 4 , wherein a molar ratio of the sulfonic-acid-derivatized carboxylic acid groups to the underivatized carboxylic acid groups varies between one surface of the implant to and an opposing surface of the implant.
19 . The orthopedic implant of claim 1 , wherein the implant comprises an interpenetrating or semi-interpenetrating polymer network that comprises a first polymeric network comprising a first polymer and a second polymeric network comprising the ionic polymer.
20 . The orthopedic implant of claim 1 , wherein the implant is configured to repair or replace cartilage in a joint in the body.
21 . The orthopedic implant of claim 20 , wherein the joint in the body is selected from a knee joint, a condyle, a patella, a tibial plateau, an ankle joint, an elbow joint, a shoulder joint, a finger joint, a thumb joint, a glenoid, a hip joint, an intervertebral disc, an intervertebral facet joint, a labrum, a meniscus, a metacarpal joint, a metatarsal joint, a toe joint, a temporomandibular joint, and a wrist joint, including portions thereof.
22 . An interpenetrating or semi-interpenetrating polymer network that comprises a first polymeric network comprising a first polymer and a second polymeric network comprising a crosslinked ionic polymer that comprises sulfonic-acid-derivatized groups.
23 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the sulfonic-acid-derivatized groups are amino-sulfonic-acid-derivatized groups.
24 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the sulfonic-acid-derivatized groups are sulfonic-acid-derivatized carboxylic groups.
25 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the crosslinked ionic polymer further comprises underivatized carboxylic acid groups.
26 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the first polymer is hydrophobic polymer.
27 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the first polymer is a thermoplastic polymer.
28 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the first polymer is a polyurethane.
29 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , wherein the polyurethane is a polyether urethane.
30 . The interpenetrating or semi-interpenetrating polymer network of claim 22 , having first and second surfaces, wherein the first surface has a composition corresponding to the first polymer and wherein a concentration of the sulfonic-acid-derivatized groups is at a maximum at the second surface and decreases with increasing distance from the second surface.
31 . The interpenetrating or semi-interpenetrating polymer network of claim 25 , wherein the hydrophobic polymer is a polyurethane and wherein at least a portion of the underivatized carboxylic acid groups correspond to underivatized acrylic acid polymerized monomers within the ionic polymer.
32 . A method comprising reacting a solid article comprising a precursor polymer that comprises underivatized carboxylic acid groups with an amino sulfonic acid compound such that an amide bond is formed between the carboxylic acid groups of the precursor polymer and the amine groups of the amino sulfonic acid compound.
33 . A packaged article comprising an orthopedic implant in accordance with claim 1 contained within a sterile package.
34 . A packaged article comprising an orthopedic implant in accordance with claim 1 and a divalent-cation-containing solution comprising one or more divalent metal cations contained within a sterile package.
35 . The orthopedic implant of claim 1 , wherein the orthopedic implant has a weight change of less than 3% per mM change in total divalent cation concentration.
36 . The orthopedic implant of claim 1 , wherein the orthopedic implant has a weight change of less than 3% per mM change in total divalent cation concentration, over a total divalent cation concentration range of about 0.1 mM to about 5 mM.
37 . The orthopedic implant of claim 1 , wherein the orthopedic implant has a weight change of less than 3% per mM change in total divalent cation concentration, over a physiologic total divalent cation concentration range of about 1.4 mM to about 2.2 mM.
38 . The orthopedic implant of claim 1 , wherein the orthopedic implant maintains a coefficient of friction of less than 0.1 over a total divalent cation concentration range of about 0.1 mM to about 5 mM.
39 . The orthopedic implant of claim 1 , wherein the orthopedic implant maintains a coefficient of friction of less than 0.1 over a physiologic total divalent cation concentration range of about 1.4 mM to about 2.2 mM.