Systems and methods for measuring oxygenation or hemoglobin concentration
Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.
1. A desktop-sized console for measuring hemoglobin concentration in a subject, said console comprising:
a laser diode subsystem for emitting light pulses directed to tissue of a subject, the laser diode subsystem comprising:
a first laser diode configured to emit a first light pulse at a first output wavelength in a range of 790 nm to 820 nm,
a first thermoelectric cooler coupled to the first laser diode to regulate a temperature of the first laser diode,
a first cooling fan, and
at least one controller coupled to and configured to control the first cooling fan and the first thermoelectric cooler to regulate the temperature of the first laser diode to stabilize the output wavelength of the first laser diode within an optimal range;
an acoustic sensor subsystem for measuring acoustic pressure generated in the tissue in response to the emitted light pulse; and
a processor coupled to the laser diode subsystem to control the laser diode subsystem and coupled to the acoustic sensor subsystem to receive the measured acoustic pressure, wherein the processor is configured to determine hemoglobin concentration of the subject in response to the received acoustic pressure.
2. The console of claim 1 , wherein the laser diode subsystem further comprises a second laser diode configured to emit a second light pulse at a second output wavelength different from the first output wavelength and a second thermoelectric cooler coupled to the second laser diode to regulate a temperature of the second laser diode, and wherein the at least one controller is further coupled to the second thermoelectric cooler to regulate the temperature of the second laser diode and to stabilize the output wavelength of the second laser diode within an optimal range.
3. The console of claim 2 , wherein the laser diode subsystem further comprises a third laser diode configured to emit a third light pulse at a third output wavelength different from the first and second output wavelengths and a third thermoelectric cooler coupled to the third laser diode to regulate a temperature of the third laser diode, and wherein the at least one controller is further coupled to the third thermoelectric cooler to regulate the temperature of the third laser diode and to stabilize the output wavelength of the third laser diode within an optimal range.
4. The console of claim 3 , wherein the laser diode subsystem further comprises a first temperature sensor to measure the temperature of the first laser diode, a second temperature sensor to measure the temperature of the second laser diode, and a third temperature sensor to measure the temperature of the third laser diode, and wherein the at least one controller is configured to regulate the temperatures of the first, second, and third laser diodes in response to the temperatures measured by the first, second, and third temperature sensors.
5. The console of claim 3 , wherein the first, second, or third wavelength is at an isosbestic point of oxyhemoglobin and deoxyhemoglobin.
6. The console of claim 1 , wherein the laser diode subsystem further comprises a first temperature sensor to measure the temperature of the first laser diode, and wherein the controller is configured to regulate the temperatures of the first laser diode in response to the temperatures measured by the first temperature sensor.
7. The console of claim 1 , wherein the first wavelength is at an isosbestic point of oxyhemoglobin and deoxyhemoglobin.
8. The console of claim 1 , further comprising a power supply coupled to the laser diode subsystem, the acoustic sensor subsystem, and the processor.
9. The console of claim 1 , further comprising a display coupled to the processor to display the determined hemoglobin concentration to a user.
10. The console of claim 9 , wherein the display comprises a touch screen for operating the console.
11. The console of claim 1 , further comprising a desktop-sized housing enclosing the laser diode subsystem, the acoustic sensor subsystem, and the processor.
12. The console of claim 11 , further comprising a second cooling fan coupled to one or more of the processor or acoustic sensor subsystem for cooling the console.
13. The console of claim 1 , wherein the processor is further configured to read or write to medical records of the subject.
14. The console of claim 1 , further comprising an output port for the laser diode subsystem and an input port for the acoustic sensor subsystem.
15. The console of claim 14 , wherein the output port and the input port are configured to be coupled to a sensor module or an optoacoustic probe to emit the first light pulse to the tissue of the subject and to receive the acoustic pressure generated in the tissue.
16. The console of claim 15 , wherein the output port and the input port are configured to be coupled to the sensor module or optoacoustic probe with a cable comprising one or more optical fibers.