Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
The present invention relates to a chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum including water-soluble chewing gum ingredients mixed into water-insoluble gum base, wherein the gum base has one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the one or more elastomer plasticizers includes one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base, and wherein the chewing gum has one or more cannabinoids.
1. A chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base, the water-insoluble gum base including gum base polymers,
the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 10-40% by weight of the gum base,
wherein the one or more elastomer plasticizers comprises one or more polyvinyl acetate elastomer plasticizers in an amount of 10-40% by weight of the gum base,
wherein the gum base polymers comprise less than 5% by weight of vinyl laurate-vinyl acetate copolymer, and
wherein the chewing gum comprises one or more cannabinoids.
2. The chewing gum according to claim 1 , wherein the one or more cannabinoids is homogeneously distributed in the water-insoluble gum base comprising the one or more polyvinyl acetate elastomer plasticizers.
3. The chewing gum according to claim 1 , wherein the one or more cannabinoids is embedded in the water-insoluble gum base comprising the one or more polyvinyl acetate elastomer plasticizers.
4. The chewing gum according to claim 1 , wherein the release rate of the one or more cannabinoids is at least 10% by weight of the one or more cannabinoids within the first 5 minutes upon oral administration.
5. The chewing gum according to claim 1 , wherein the one or more cannabinoids is mixed into the water-insoluble gum base in unbound form.
6. The chewing gum according to claim 1 , wherein at least 10% by weight of the one or more cannabinoids is present in unbound form.
7. The chewing gum according to claim 1 , wherein the one or more elastomer plasticizers is present in an amount of 10-35% by weight of the gum base and comprises the one or more polyvinyl acetate elastomer plasticizers in an amount of 15-35% by weight of the gum base.
8. The chewing gum according to claim 1 , wherein the one or more natural resins is present in an amount of 15-35% by weight of the gum base.
9. The chewing gum according to claim 1 , wherein the chewing gum comprises water-soluble chewing gum ingredients in an amount of 40-70% by weight of the chewing gum.
10. The chewing gum according to claim 1 , wherein the one or more cannabinoids is mixed into the water-insoluble gum base together with sugar alcohols or saccharose after a period of more than half the total mixing time.
11. The chewing gum according to claim 1 , wherein the one or more cannabinoids is mixed into the water-insoluble gum base as part of a pre-mixture with water-soluble chewing gum ingredients.
12. The chewing gum according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), and combinations thereof.
13. The chewing gum according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), and combinations thereof.
14. The chewing gum according to claim 1 , wherein the one or more cannabinoids comprises cannabigerol (CBG).
15. The chewing gum according to claim 1 , wherein the one or more cannabinoids comprises at least two cannabinoids.
16. The chewing gum according to claim 1 , wherein the one or more cannabinoids is present in a pre-mixture with one or more sugar alcohols or saccharose.
17. The chewing gum according to claim 1 , wherein the one or more cannabinoids forms part of a complex with cyclodextrin.
18. The chewing gum according to claim 1 , wherein the one or more cannabinoids comprises at least one phytocannabinoid that forms part of an extract.
19. The chewing gum according to claim 1 , wherein the chewing gum further comprises terpenes.
20. The chewing gum according to claim 1 , wherein the one or more cannabinoids comprises at least one isolated cannabinoid.
21. The chewing gum according to claim 1 , wherein the one or more cannabinoids comprises at least one water-soluble cannabinoid.
22. The chewing gum according to claim 1 , wherein the chewing gum comprises a self-emulsifying agent.
23. The chewing gum according to claim 1 , wherein the one or more cannabinoids is comprised in an outer coating of the chewing gum.
24. The chewing gum according to claim 1 , wherein the gum base does not comprise vinyl laurate-vinyl acetate copolymers.
25. A chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base,
the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base,
wherein the one or more elastomer plasticizers comprises one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base,
wherein the chewing gum comprises one or more cannabinoids,
wherein the gum base comprises less than 50% by weight of gum base polymers,
and
wherein the gum base polymers comprise less than 5% by weight of vinyl laurate-vinyl acetate copolymer.
26. A chewing gum for mucosal delivery of cannabinoids, the chewing gum being formulated as an extruded chewing gum comprising water-soluble chewing gum ingredients mixed into water-insoluble gum base,
the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base,
wherein the one or more elastomer plasticizers comprises one or more polyvinyl acetate elastomer plasticizers in an amount of 8-50% by weight of the gum base,
wherein the gum base does not comprise vinyl laurate-vinyl acetate copolymers, and
wherein the chewing gum comprises one or more cannabinoids.
27. The chewing gum according to claim 26 , wherein the one or more elastomer plasticizers is present in an amount of 10-40% by weight of the gum base and comprises the one or more polyvinyl acetate elastomer plasticizers in an amount of 10-40% by weight of the gum base.