Process for the preparation of isosulfan blue
Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2, 5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater.
1. A process of preparing isosulfan blue sodium salt, said process comprising:
i) combining isoleuco acid of the formula (4):
with an oxidizing agent,
ii) recovering isosulfan blue acid, and
iii) obtaining isosulfan blue sodium salt therefrom.
2. The process of claim 1 , wherein combining said isoleuco acid of formula (4) with said oxidizing agent occurs in a polar solvent.
3. The process of claim 2 , wherein said polar solvent is selected from the group consisting of water, alcohol, and mixtures thereof.
4. The process of claim 2 , wherein said polar solvent is methanol.
5. The process of claim 1 , wherein said oxidizing agent is silver oxide.
6. The process of claim 1 , wherein said process of obtaining an isosulfan blue sodium salt comprises combining said isosulfan blue acid with a sodium solution.
7. The process of claim 6 , wherein said sodium solution is an aqueous sodium solution.
8. The process of claim 1 , wherein said isosulfan blue sodium salt is obtained in a purity of at least 99% as measured by HPLC.
9. The process of claim 8 , wherein said isosulfan blue sodium salt is obtained in a purity of at least 99.5% as measured by HPLC.
10. A process of preparing isosulfan blue sodium salt, said process comprising:
iv) combining isoleuco acid of the formula (4):
with an oxidizing agent,
v) forming isosulfan blue acid, and
vi) obtaining isosulfan blue sodium salt therefrom.
11. The process of claim 10 , wherein combining said isoleuco acid of formula (4) with said oxidizing agent occurs in a polar solvent.
12. The process of claim 11 , wherein said polar solvent is selected from the group consisting of water, alcohol, and mixtures thereof.
13. The process of claim 11 , wherein said polar solvent is methanol.
14. The process of claim 10 , wherein said oxidizing agent is silver oxide.
15. The process of claim 10 , wherein said process of obtaining an isosulfan blue sodium salt comprises combining said isosulfan blue acid with a sodium solution.
16. The process of claim 15 , wherein said sodium solution is an aqueous sodium solution.
17. The process of claim 10 , wherein said isosulfan blue sodium salt is obtained in a purity of at least 99% as measured by HPLC.
18. The process of claim 17 , wherein said isosulfan blue sodium salt is obtained in a purity of at least 99.5% as measured by HPLC.