Needle assisted injection administration of testosterone compositions
The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.
1. A method of obtaining steady state average blood concentration of testosterone comprising:
the step of repeatedly administering a dose of testosterone over a prescribed time period such that a steady state blood plasma level of testosterone is obtained after three or more doses,
wherein once steady state is reached, the average blood plasma concentration obtained after administration of a subsequent dose or doses is less than + or −30% of the average plasma concentration obtained after an immediately preceding dose.
2. The method of claim 1 , wherein the dose is selected from between 50 mg, 75 mg and 100 mg.
3. The method of claim 2 , wherein the concentration of the administered dose is 100 mg/ml, 150 mg/ml or 200 mg/ml.
4. The method of claim 1 , wherein the dose is between 50 mg and 100 mg.
5. The method of claim 1 , wherein the prescribed time period is weekly dosing.
6. The method of claim 1 , wherein steady state is reached after the fourth dose.
7. The method of claim 1 , wherein steady state is reached after the fifth dose.
8. The method of claim 1 , wherein the doses are continued after steady state is reached.
9. The method of claim 8 , wherein the doses administered after steady state is reached are the same or different than the dose administered prior to reaching steady state.
10. The method of claim 1 , wherein the steady state therapeutic blood levels maintained at steady state after multiple dosings is about 800 ng/dl to about 1100 ng/dl.
11. The method of claim 1 , wherein the steady state therapeutic blood levels maintained at steady state after multiple dosings is about 500 ng/dl to about 800 ng/dl.
12. The method of claim 1 , wherein the steady state therapeutic blood levels maintained at steady state after multiple dosings is about 350 ng/dl to about 500 ng/dl.
13. The method of claim 1 , wherein the dose of testosterone comprises a liquid.
14. The method of claim 1 , wherein repeatedly administering the dose of testosterone includes injecting the dose of testosterone.