Materials and methods for delivering compositions to selected tissues
This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.
1. A composition comprising:
a porous particulate material comprising silicon dioxide, the porous particulate material having been heated in an oxidizing environment at a temperature at or above 800° C.; and
a drug or biologically active material within the porous particulate material.
2. The composition of claim 1 , wherein the porous particulate material is a microscopic porous particulate material.
3. The composition of claim 1 , wherein the porous particulate material displays a particle size of between about 0.1 μm and 100 μm.
4. The composition of claim 1 , wherein the porous particulate material displays a particle size of between about 1 μm and 100 μm.
5. The composition of claim 1 , wherein the porous particulate material displays a porosity of between about 40% and 80%.
6. The composition of claim 1 , wherein the porous particulate material displays a layered nanostructure.
7. The composition of claim 1 , wherein the porous particulate material further comprises a polymeric material.
8. The composition of claim 1 , wherein the drug or biologically active material is selected from the group consisting of: an angiostatic steroid, a metalloproteinase inhibitor, a VEGF binding drug, a pigment epithelium derived factor, an 8-mer peptide fragment of urokinase, a modified RNA, a modified DNA, a fragment derived from an immunoglobulin, and dexamethasone.
9. The composition of claim 1 , wherein the drug or biologically active material is bevacizumab, ranibizumab, or pegaptanib.
10. The composition of claim 1 , wherein the pores are selectively dimensioned to obtain a desired reflective wavelength.
11. A pharmaceutical composition comprising the composition of claim 1 and a pharmaceutically acceptable carrier.