Compositions and methods for treating metabolic disorders
Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
1. A method of treating a metabolic disorder in a patient having a condition that contraindicates for treatment with a biguanide compound, comprising administering an oral delayed-release formulation of a biguanide compound selected from metformin, phenformin, buformin, or imeglimin, or a salt thereof, wherein said delayed-release formulation releases the biguanide compound downstream of duodenum to one or more regions of intestine, wherein the biguanide compound in said formulation has a bioavailability no more than 80% of the bioavailability of the biguanide compound in an immediate-release composition having the same amount of biguanide compound, wherein the metabolic disorder comprises a hyperglycemic condition, a disorder of lipid metabolism, or both a hyperglycemic condition and a disorder of lipid metabolism, whereby resulting circulating plasma concentration of the biguanide compound is below about 1 μg/mL, and wherein the condition that contraindicates for treatment with a biguanide compound is a gastrointestinal condition caused by biguanide administration, dizziness, headache, or renal impairment, wherein the gastrointestinal condition caused by biguanide administration is nausea, vomiting, or dyspepsia.
2. The method of claim 1 , wherein the gastrointestinal condition is nausea.
3. The method of claim 1 , wherein the gastrointestinal condition is vomiting.
4. The method of claim 1 , wherein the gastrointestinal condition is dyspepsia.
5. The method of claim 1 , wherein the condition that contraindicates for treatment with a biguanide compound is dizziness.
6. The method of claim 1 , wherein the condition that contraindicates for treatment with a biguanide compound is headache.
7. The method of claim 1 , wherein the condition that contraindicates for treatment with a biguanide compound is renal impairment.