IP Library › Granted Patent US 10,710,986
Granted Patent B2
US 10,710,986 · App. 16/274,106 · Granted Jul 14, 2020

PD-1/PD-L1 inhibitors

Inventors: Evangelos Aktoudianakis (Redwood City, CA); Aesop Cho (Mountain View, CA); Zhimin Du (Belmont, CA); Michael Graupe (Pacifica, CA); Lateshkumar Thakorlal Lad (Belmont, CA); Paulo A. Machicao Tello (San Mateo, CA); Jonathan William Medley (San Mateo, CA); Samuel E. Metobo (Newark, CA); Prasenjit Kumar Mukherjee (South San Francisco, CA); Devan Naduthambi (San Bruno, CA); Eric Q. Parkhill (San Francisco, CA); Barton W. Phillips (San Mateo, CA); Scott Preston Simonovich (Oakland, CA); Neil H. Squires (San Francisco, CA); Peiyuan Wang (San Mateo, CA); William J. Watkins (Saratoga, CA); Jie Xu (Foster City, CA); Kin Shing Yang (San Mateo, CA); Christopher Allen Ziebenhaus (San Francisco, CA)
Assignee: Gilead Sciences, Inc.
C07D403/14A61K31/496A61K31/497A61P31/20A61P35/00A61P35/02C07D241/18C07D241/20C07D405/14C07D487/08C07D487/10C07D491/107C07D519/00C07K16/2818C07K16/2827
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Quick Facts
Patent No.
US 10,710,986
App. No.
16/274,106
Granted
Jul 14, 2020
Kind
B2
Abstract

Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Claims (6)

1. A compound which is:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

3. The pharmaceutical composition of claim 2 , further comprising one or more additional therapeutic agents.

4. The pharmaceutical composition of claim 3 , wherein the additional therapeutic agent is an anticancer agent selected from nivolumab, pembrolizumab, atezolizumab, and ipilimumab.

5. A method for treating hepatitis B virus comprising administering a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, to a patient in need thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2019
From: AKTOUDIANAKIS, EVANGELOS; CHO, AESOP; DU, ZHIMIN; GRAUPE, MICHAEL; LAD, LATESHKUMAR THAKORLAL; TELLO, PAULO A. MACHICAO; MEDLEY, JONATHAN WILLIAM; METOBO, SAMUEL E.; MUKHERJEE, PRASENJIT KUMAR; NADUTHAMBI, DEVAN; PARKHILL, ERIC Q.; PHILLIPS, BARTON W.; SIMONOVICH, SCOTT PRESTON; SQUIRES, NEIL H.; WANG, PEIYUAN; WATKINS, WILLIAM J.; XU, JIE; YANG, KIN SHING; ZIEBENHAUS, CHRISTOPHER ALLEN
To: GILEAD SCIENCES, INC.
Reel/Frame 048396/0295 →
Continuity (5)
Provisional Application 62747029 · Oct 17, 2018
Provisional Application 62763116 · Apr 19, 2018
Provisional Application 62640534 · Mar 8, 2018
Provisional Application 62630187 · Feb 13, 2018
Related Publication 20190270727A1 · Sep 5, 2019
Cited By (2)
US 12,269,812 US 12,590,062