Theranostics for protein misfolding diseases
Novel agents and theranostics for use as controllable and selective photosensitizers for the diagnosis, treatment and/or tracking of amyloid protein aggregates and amyloid diseases.
1. A method for diagnosing and treating a patient with an amyloid-related disease, condition, or disorder comprising: delivering a theranostic agent comprising a detectable amyloid protein aggregate (APA)-specific agent capable of singlet oxygen generation under suitable conditions that the APA-specific agent can specifically bind to APAs associated with the amyloid-related disease, condition, or disorder without binding to the native protein; detecting the presence of the bound theranostic agent and irradiating a region of the patient believed to be associated with the disease so as to activate the bound APA specific agent and generate singlet oxygen resulting in selective oxidation of the bound APAs, wherein the theranostic agent comprises an oligomeric p-phenylene ethynylene (OPE).
2. The method of claim 1 wherein the OPE is OPE 1−.
3. The method of claim 1 wherein the OPE is OPE 2+.
4. The method of claim 1 comprising delivering the theranostic agent at least twice and comparing the presence of the bound theranostic agent after each delivery so as to produce an analysis of the progression of the amyloid-related disease, condition, or disorder.
5. The method of claim 1 wherein the theranostic agent is able to cross the blood-brain barrier.
6. The method of claim 1 wherein the amyloid-related disease is Parkinson's disease.
7. The method of claim 1 wherein the amyloid-related disease is Alzheimer's disease.