Aminosteroids for the treatment of a PTP1B associated disease
This application is directed to the use of aminosteroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
1. A compound of formula
or a pharmaceutically acceptable salt thereof,
wherein:
R 2 =H;
R 3 =OH;
R 4 =H; and
2. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable diluent or carrier.
5. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable diluent or carrier.
6. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable diluent or carrier.
7. A compound of formula
or a pharmaceutically acceptable salt thereof,
wherein:
X 2 =H;
X 3 =OH;
X 4 =H; and
X 5 =H or CH 3 .
8. A pharmaceutical composition comprising the compound of claim 7 and a pharmaceutically acceptable diluent or carrier.