Combination treatment of ocular inflammatory disorders and diseases
The present disclosure provides a combination of a fused bicyclic amine compound and an anti-inflammatory agent for treating ocular inflammatory disorders and diseases. Further provided are pharmaceutical compositions of the compound and the anti-inflammatory agent.
1. A method of treating non-infectious anterior uveitis, comprising administering to a subject with non-infectious anterior uveitis a therapeutically effective amount of Compound (2):
or a pharmaceutically acceptable salt thereof;
and prednisolone.
2. The method of claim 1 , wherein Compound (2) is formulated with a β-cyclodextrin or derivatives thereof.
3. The method of claim 2 , wherein the β-cyclodextrin or derivatives thereof is sulfobutylether-β-cyclodextrin or hydroxypropyl-β-cyclodextrin.
4. The method of claim 1 , wherein Compound (2) is administered topically at a concentration of about 0.1% w/v to about 5% w/v.