Low dose antibody-based methods for treating hematologic malignancies
This invention provides a method for treating a subject afflicted with a hematologic malignancy comprising administering to the subject an agent targeting a hematologic malignancy-associated antigen, wherein the subject has a low peripheral cancerous cell burden. This invention also provides a method for treating a subject afflicted with a hematologic malignancy and having a high peripheral cancerous cell burden, comprising (i) medically lowering the subject's peripheral cancerous cell burden, and (ii) while the subject's peripheral cancerous cell burden is still low, administering to the subject an agent targeting a hematologic malignancy-associated antigen. Particularly envisioned are the subject methods for treating acute myeloid leukemia using an anti-CD33 antibody labeled with an alpha-emitting isotope, such as 225 Ac-HuM195.
1. A method for treating a human subject afflicted with acute myeloid leukemia comprising intravenously administering to the subject 225 Ac-labeled HuM195, wherein (a) the subject has a peripheral blast burden below 200 blast cells/μl, and (b) the 225 Ac-labeled HuM195 is administered at a dose of (i) 2×1.0 μCi/kg, 2×1.5 μCi/kg, or 2×2.0 μCi/kg, wherein the fractions are administered one week apart; or (ii) 1×1.0 μCi/kg, 1×2.0 μCi/kg, 1×3.0 μCi/kg, or 1×4.0 μCi/kg.
2. The method of claim 1 , wherein the 225 Ac-labeled HuM195 is administered at a dose of 2×1.0 μCi/kg, 2×1.5 μCi/kg, or 2×2.0 μCi/kg, wherein the fractions are administered one week apart.
3. The method of claim 1 , wherein the 225 Ac-labeled HuM195 is administered at a dose of 1×1.0 μCi/kg, 1×2.0 μCi/kg, 1×3.0 μCi/kg, or 1×4.0 μCi/kg.
4. A method for treating a human subject afflicted with acute myeloid leukemia and having a peripheral blast burden at or above 200 blast cells/μl, comprising (a) medically lowering the subject's peripheral blast burden to below 200 blast cells/μl, and (b) while the subject's peripheral blast burden is still below 200 blast cells/μl, intravenously administering to the subject 225 Ac-labeled HuM195 at a dose of (i) 2×1.0 μCi/kg, 2×1.5 μCi/kg, or 2×2.0 μCi/kg, wherein the fractions are administered one week apart; or (ii) 1×1.0 μCi/kg, 1×2.0 μCi/kg, 1×3.0 μCi/kg, or 1×4.0 μCi/kg.
5. The method of claim 4 , wherein the 225 Ac-labeled HuM 195 is administered at a dose of 2×1.0 μCi/kg, 2×1.5 μCi/kg, or 2×2.0 μCi/kg, wherein the fractions are administered one week apart.
6. The method of claim 4 , wherein the 225 Ac-labeled HuM 195 is administered at a dose of 1×1.0 μCi/kg, 1×2.0 μCi/kg, 1×3.0 μCi/kg, or 1×4.0 μCi/kg.