Insulin receptor partial agonists
View Patent ↗Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
1. An insulin dimer selected from the group consisting of:
wherein the disulfide linkages between the Cys 6 and Cys 11 residues of the A-chain polypeptide and the disulfide linkages between the Cys 7 and Cys 20 of the A-chain to the Cys 7 and Cys 19 of the B-chain polypeptide, respectively, are represented by the solid line therebetween; wherein the linking moieties are covalently linked to the epsilon amino acid of the shown lysine residue wherein the A-chain polypeptide for Dimers 1-32, 35-62, 64-66, 69-79 and 82-86 has the amino acid sequence shown in SEQ ID NO: 1; and the B-chain polypeptide for Dimers 1-32, 35-62, 64-66, 69-79 and 82-86 has the amino acid sequence shown in SEQ ID NO: 2.
2. A composition comprising the insulin receptor partial agonist of claim 1 and a GLP-1 receptor agonist.
3. A method for treating diabetes comprising administering to an individual with diabetes a therapeutically effective amount of a composition comprising the insulin receptor partial agonist of claim 1 .
4. The method of claim 3 , wherein the diabetes is Type 1 diabetes, Type 2 diabetes, or gestational diabetes.
5. A composition for the treatment of diabetes comprising the insulin receptor partial agonist of claim 1 .
6. The composition of claim 5 , wherein the diabetes is Type 1 diabetes, Type 2 diabetes, or gestational diabetes.