Ring and tubular structures and methods of synthesis and use thereof
View Patent ↗Nanofiber structures are provided along with methods of production and methods of use.
1. A nanofiber ring comprising at least one compound, wherein said nanofiber ring comprises at least one rolled tubular nanofiber membrane, and wherein said nanofiber membrane comprises electrospun nanofibers.
2. The nanofiber ring of claim 1 , wherein said nanofiber ring comprises at least two different compounds.
3. The nanofiber ring of claim 2 comprising a first compound and a second compound, wherein in a cross-sectional view of the nanofiber ring, the first compound is located towards the core of the nanofiber ring and the second compound is located towards the surface of the nanofiber.
4. The nanofiber ring of claim 2 , wherein said first compound and said second compound are in distinct areas of the nanofiber ring in a cross-sectional view.
5. The nanofiber ring of claim 1 , wherein said electrospun nanofibers comprise hydrophobic polymers.
6. The nanofiber ring of claim 1 , wherein said electrospun nanofibers comprise polycaprolactone.
7. The nanofiber ring of claim 1 , wherein said compound is a small molecule.
8. The nanofiber ring of claim 1 , wherein said nanofiber ring comprises more than one nanofiber membrane.
9. The nanofiber ring of claim 8 , wherein each nanofiber membrane comprises a compound distinct from the compounds of the other nanofiber membranes.
10. The nanofiber ring of claim 8 , wherein each nanofiber membrane comprises electrospun nanofibers of a polymer distinct from the polymers of the other nanofiber membranes.
11. A method for producing a nanofiber ring of claim 1 , the method comprising:
a) electrospinning nanofibers onto a rotating cylindrical substrate to synthesize a nanofiber membrane,
b) adding at least one compound to the nanofiber membrane, thereby generating a loaded nanofiber membrane, and
c) rolling the loaded nanofiber membrane to generate said nanofiber ring.
12. The method of claim 11 , wherein step b) comprises adding the compound during the electrospinning of step a).
13. The method of claim 11 , wherein step b) comprises adding the compound after the nanofiber membrane is formed.
14. The method of claim 11 , wherein step b) comprises adding the compound evenly throughout the nanofiber membrane.
15. The method of claim 11 , wherein step b) comprises adding the compound to distinct locations of the nanofiber membrane.
16. The method of claim 11 , further comprising repeating steps a), b), and c) at least once, thereby generating a nanofiber ring or tube comprising more than one nanofiber membrane.
17. A method of treating a disease or disorder in a subject in need thereof, said method comprising administering a nanofiber ring of claim 1 to the subject.
18. The method of claim 17 , wherein said disease or disorder is cancer and the compound of the nanofiber ring or tube is an anticancer agent.
19. The method of claim 18 , wherein said cancer is pancreatic cancer and said anticancer agent is gemcitabine.
20. The method of claim 18 , wherein said administration comprises implanting the nanofiber ring into or near cancerous tissue.
21. A method for sequentially delivering at least two compounds to a subject, said method comprises administering a nanofiber ring of claim 1 to the subject, wherein said nanofiber ring comprises at least a first compound and at least a second compound, wherein said first compound is located towards the core of a cross-section of the nanofiber ring and said second compound is located towards the surface of a cross-section of the nanofiber ring.
22. The method of claim 21 , wherein said first and second compounds are in distinct locations within the nanofiber ring.
23. The nanofiber ring of claim 1 , wherein the nanofiber ring has a circular cross-section.
24. The nanofiber ring of claim 3 , wherein said first compound is contained within the middle 50% by area of the cross-sectional view and said second compound is contained outside of the middle 50% by area of the cross-sectional view.