5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis

1. A compound according to Formula I:

Wherein

R 1 is:

H,

C 1-4 alkyl optionally substituted with one or more independently selected R 4 groups,

C 3-7 monocyclic cycloalkyl optionally substituted with one or more independently selected R 4 groups,

4-7 membered monocyclic heterocycloalkyl comprising 1 to 2 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected C 1-4 alkyl, —C(═O)C 1-4 alkyl, or —C(═O)OC 1-4 alkyl,

phenyl optionally substituted with one or more independently selected R 5 groups,

phenyl fused to a 5-6 membered monocyclic heterocycloalkyl comprising 1, 2 or 3 heteroatoms independently selected from N, O, and S, which heterocycloalkyl is optionally substituted with one or more ═O,

5-6 membered monocyclic heteroaryl comprising 1 or 2 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected R 5 groups;

R 2 is independently selected from:

H,

OH,

C 1-4 alkoxy, and

C 1-4 alkyl optionally substituted with one

OH,

—CN,

C 1-4 alkoxy optionally substituted with one phenyl, and

5-6 membered monocyclic heteroaryl comprising 1 or 2 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected C 1-4 alkyl;

each R 3a , and R 3b is independently selected from H, and C 1-4 alkyl optionally substituted with one or more halo;

Cy is

6-10 membered monocyclic or fused bicyclic aryl,

5-10 membered monocyclic or fused bicyclic heteroaryl comprising 1, 2 or 3 heteroatoms independently selected from N, O, and S;

R 4 is

halo,

OH,

—CN,

C 1-4 alkyl,

C 1-4 alkoxy optionally substituted with one C 1-4 alkoxy, or phenyl,

C 1-4 thioalkoxy,

4-7-membered monocyclic heterocycloalkyl comprising one or more heteroatoms independently selected from N, S, and O, optionally substituted with one or more halo, or —C(═O)OC 1-4 alkyl,

phenyl,

—S(═O) 2 C 1-4 alkyl

—C(═O)OR 7a

—C(═O)NR 7b R 7c

—NHC(═O)OR 7d

—NHC(═O)R 7e

—NR 8a R 8b ;

each R 5 is

halo,

OH,

—CN,

C 1-4 alkyl optionally substituted with one or more independently selected halo, —NR 9a R 9b , or —C(═O)NR 9c R 9d ,

C 1-4 alkoxy optionally substituted with —NR 9e R 9f , or

—S(═O) 2 C 1-4 alkyl;

each R 6a is

C 1-4 alkoxy optionally substituted with one or more halo,

the subscript n is 0, 1, 2 or 3

each R 6b is independently selected from

halo,

—CN,

—NO 2 ,

—C 1-4 alkyl,

—C 1-4 alkoxy

5-10 membered monocyclic or fused bicyclic heteroaryl comprising 1, 2 or 3 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected halo, C 1-4 alkyl, or C 1-4 alkoxy, and

—NR 9g R 9h ;

each R 7a , R 7b , R 7c , R 7d , or R 7e , is H, or C 1-4 alkyl optionally substituted with OH or C 1-4 alkoxy;

each R 8a , or R 8b is independently selected from H, and C 1-4 alkyl optionally substituted with OH, C 1-4 alkoxy, or phenyl;

each R 9a , R 9b , R 9c , R 9d , R 9e , R 9f , R 9g , R 9h is independently selected from H, and C 1-4 alkyl;

or a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof;

provided that when R 1 , R 2 , R 3a and R 3b are H, Cy is phenyl and R 6a is —OCH 3 , then the subscript n is not 0, and the compound is not (5R)-5-[3-[(3S)-4-(4-chloro-3-methoxy-5-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione.

2. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 1 is H, C 1-4 alkyl substituted with one C 1-4 alkoxy, or C 3-7 monocyclic cycloalkyl.

3. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 2 is H, or C 1-4 alkyl.

4. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 3a is H.

5. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 3b is C 1-4 alkyl.

6. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is according to Formula Va, Vb, Vc, or Vd:

7. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein Cy is phenyl.

8. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 6a is —OCH 3 or —OCH 2 CH 3 , each of which is optionally substituted with one or more F.

9. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein the subscript n is 0.

10. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein the subscript n is 1 or 2.

11. A compound of pharmaceutically acceptable salt thereof according to claim 10 , wherein R 6b is halo, C 1-4 alkyl, or C 1-4 alkoxy.

12. A compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is:

5-[3-[4-(3-methoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[4-(3-methoxyphenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-methyl-5-[3-oxo-3-[4-[4-(trifluoromethoxy)phenyl]piperazin-1-yl]propyl]imidazolidine-2,4-dione,

5-methyl-5-[3-oxo-3-[4-[2-(trifluoromethoxy)phenyl]piperazin-1-yl]propyl]imidazolidine-2,4-dione,

5-[3-[4-(4-methoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3-methoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-(3-pyridyl)imidazolidine-2,4-dione,

5-[3-[4-(2-methoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3-methoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-(2-pyridyl)imidazolidine-2,4-dione,

5-[3-[4-(4-fluoro-3-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3,5-dimethoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3-chloro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(3-ethoxyphenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[4-(4-fluoro-3-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(R)-5-[3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(R)-5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-(3-pyridyl)imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3,5-dimethoxyphenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5S)-5-cyclopropyl-5-[(2S)-3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[(2S)-3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-(3-pyridyl)imidazolidine-2,4-dione,

5-cyclopropyl-5-[(2S)-3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3,5-dimethoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3,5-dimethoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(5-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-5-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(5-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-5-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5S)-5-cyclopropyl-5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3,5-dimethoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3,5-dimethoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-5-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-[3-[4-(3,4-dichloro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(2-pyridyl)imidazolidine-2,4-dione,

5-[3-[4-(3-chloro-4-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-[(3,3-difluoropyrrolidin-1-yl)methyl]imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3-chloro-4-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5S)-5-[(2S)-3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(2-pyridyl)imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[(2R)-3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-(hydroxymethyl)-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[(2S)-3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-ethyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-2-methoxy-5-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5S)-5-[(2S)-3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[(3S)-4-(5-methoxy-3-pyridyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-(6-methyl-2-pyridyl)imidazolidine-2,4-dione,

(5S)-5-[3-[(3S)-4-(3-chloro-4-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-cyclopropyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3-chloro-4-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[(3S)-4-(5-methoxy-3-pyridyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]imidazolidine-2,4-dione,

(5S)-5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-cyclopropyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-fluoro-5-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-fluoro-5-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3-chloro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3-chloro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-fluoro-3,5-dimethoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(5-chloro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-fluoro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethoxy-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-ethoxy-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-fluoro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3-fluoro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(5-fluoro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3-fluoro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-[4-chloro-3-(trifluoromethoxy)phenyl]-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-[4-chloro-3-(trifluoromethoxy)phenyl]piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-fluoro-3,5-dimethoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3,4-dichloro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(5-chloro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4,5-dichloro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-fluoro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4,5-dichloro-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-2-methoxy-5-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3-chloro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-2,5-dimethoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-[4-chloro-3-(dimethylamino)-5-methoxy-phenyl]-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-[4-chloro-3-(trifluoromethoxy)phenyl]-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-(6-methyl-2-pyridyl)imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-5-ethyl-2-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-5-ethyl-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-2,5-dimethoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-methoxy-5-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-ethyl-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-ethyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-[5-methoxy-2-(trifluoromethoxy)phenyl]-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-isopropyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3,5-dimethoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-ethoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-methoxy-5-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4,5-difluoro-2-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethyl-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-ethyl-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-methoxy-phenyl)-3-(trifluoromethyl)piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

(5R)-5-[(2S)-3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5S)-5-[(2S)-3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-methoxy-5-methyl-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[(3S)-4-(4-chloro-3-methoxy-5-methyl-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

(5R)-5-[3-[(3R)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3,4-difluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3,5-dimethoxyphenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-cyclopropyl-5-[3-[(3S)-4-(3,4-difluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3,5-dimethoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(5-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-5-methoxy-2-methyl-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3,5-dimethoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(5-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-5-methoxy-2-methyl-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3,4-dichloro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5S)-5-[3-[(3S)-4-(4-chloro-3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3-chloro-4-fluoro-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(3-chloro-4-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethoxy-5-methoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[(3S)-4-(4-chloro-3-ethoxy-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione, or

(5R)-5-[3-[4-(4-fluoro-3,5-dimethoxy-phenyl)piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione.

13. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 1 , and a pharmaceutically acceptable carrier.

14. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 1 , to said human.

15. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 13 , to said human.

16. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 2 , and a pharmaceutically acceptable carrier.

17. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 3 , and a pharmaceutically acceptable carrier.

18. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 4 , and a pharmaceutically acceptable carrier.

19. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 5 , and a pharmaceutically acceptable carrier.

20. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 6 , and a pharmaceutically acceptable carrier.

21. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 7 , and a pharmaceutically acceptable carrier.

22. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 8 , and a pharmaceutically acceptable carrier.

23. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 9 , and a pharmaceutically acceptable carrier.

24. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 10 , and a pharmaceutically acceptable carrier.

25. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 11 , and a pharmaceutically acceptable carrier.

26. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 12 , and a pharmaceutically acceptable carrier.

27. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 16 , to said human.

28. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 17 , to said human.

29. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 18 , to said human.

30. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 19 , to said human.

31. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 20 , to said human.

32. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 21 , to said human.

33. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 22 , to said human.

34. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 23 , to said human.

35. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 24 , to said human.

36. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 25 , to said human.

37. A method of treating inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 26 , to said human.