5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis

1. A compound according to Formula I:

wherein

R 1 is:

H,

C 1-4 alkyl optionally substituted with one or more independently selected R 4 groups,

C 3-7 monocyclic cycloalkyl optionally substituted with one or more independently selected R 4 groups,

4-7 membered monocyclic heterocycloalkyl comprising 1 to 2 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected C 1-4 alkyl, —C(═O)C 1-4 alkyl, or —C(═O)OC 1-4 alkyl,

phenyl optionally substituted with one or more independently selected R 5 groups,

phenyl fused to a 5-6 membered monocyclic heterocycloalkyl comprising 1, 2 or 3 heteroatoms independently selected from N, O, and S, which heterocycloalkyl is optionally substituted with one or more ═O,

5-6 membered monocyclic heteroaryl comprising 1 or 2 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected R 5 groups;

R 2 is independently selected from:

H,

OH,

C 1-4 alkoxy, and

C 1-4 alkyl optionally substituted with one

OH,

—CN,

C 1-4 alkoxy optionally substituted with one phenyl, and

5-6 membered monocyclic heteroaryl comprising 1 or 2 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected C 1-4 alkyl;

each R 3a , and R 3b is independently selected from H, and C 1-4 alkyl;

Cy is

6-10 membered monocyclic or fused bicyclic aryl,

5-10 membered monocyclic or fused bicyclic heteroaryl comprising 1, 2 or 3 heteroatoms independently selected from N, O, and S;

R 4 is

halo,

OH,

—CN,

C 1-4 alkyl,

C 1-4 alkoxy optionally substituted with one C 1-4 alkoxy, or phenyl,

C 1-4 thioalkoxy,

4-7-membered monocyclic heterocycloalkyl comprising one or more heteroatoms independently selected from N, S, and O, optionally substituted with one or more halo, or —C(═O)OC 1-4 alkyl,

phenyl,

—S(═O) 2 C 1-4 alkyl

—C(═O)OR 7a

—C(═O)NR 7b R 7c

—NHC(═O)OR 7d

—NHC(═O)R 7e

—NR 8a R 8b ;

each R 5 is

halo,

OH,

—CN,

—C 1-4 alkyl optionally substituted with one or more independently selected halo, —NR 9a R 9b , or —C(═O)NR 9c R 9d ,

C 1-4 alkoxy optionally substituted with —NR 9e R 9f , or

—S(═O) 2 C 1-4 alkyl;

the subscript n is 0, 1, 2 or 3;

each R 6 is independently selected from:

halo,

—CN,

—NO 2 ,

—C 1-4 alkyl optionally substituted with one or more halo,

—C 1-4 alkoxy optionally substituted with one or more halo,

5-10 membered monocyclic or fused bicyclic heteroaryl comprising 1, 2 or 3 heteroatoms independently selected from N, O, and S, optionally substituted with one or more independently selected halo, C 1-4 alkyl, or C 1-4 alkoxy, and

—NR 9g R 9h ;

each R 7a , R 7b , R 7c , R 7d , or R 7e , is H, or C 1-4 alkyl optionally substituted with one OH or C 1-4 alkoxy;

each R 8a , or R 8b is independently selected from H, and C 1-4 alkyl optionally substituted with OH, C 1-4 alkoxy, or phenyl;

each R 9a , R 9b , R 9c , R 9d , R 9e , R 9f , R 9g , and R 9h is independently selected from H, and C 1-4 alkyl;

or a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof; or a biologically active metabolite thereof;

provided that the compound is not

5-[3-oxo-3-[4-(4-pyridinyl)-1-piperidinyl]propyl]-2,4-Imidazolidinedione CAS#1422565-71-6,

5(S)-[3-oxo-3-[4-(1H-1,2,4-triazol-5-yl)-1-piperidinyl]propyl]-2,4-imidazolidinedione CAS#1638335-41-7,

5(S)-[3-[4-(2-methoxyphenyl)-1-piperidinyl]-3-oxopropyl]-2,4-Imidazolidinedione CAS#1781306-72-6,

5-[3-[4-(5-methyl-4-pyrimidinyl)-1-piperidinyl]-3-oxopropyl]-2,4-Imidazolidinedione CAS#1638336-99-8,

5-[3-[4-(7-methyl-1H-benzimidazol-2-yl)-1-piperidinyl]-3-oxopropyl]-2,4-Imidazolidinedione CAS#1422561-83-8,

5-[3-[4-(6-fluoro-1H-benzimidazol-2-yl)-1-piperidinyl]-3-oxopropyl]-2,4-Imidazolidinedione CAS#1377848-53-7,

5-[3-[4-(3,5-dimethylimidazo[5,1-b]thiazol-7-yl)-1-piperidinyl]-3-oxopropyl]-2,4-Imidazolidinedione CAS#1287426-16-7, or

5-[3-[4-[4-methyl-5-(2-methyl-4-pyrimidinyl)-2-thiazolyl]-1-piperidinyl]-3-oxopropyl]-2,4-Imidazolidinedione CAS#1381179-03-8.

2. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 1 is H, C 1-4 alkyl substituted with one C 1-4 alkoxy, or C 3-7 monocyclic cycloalkyl.

3. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is according to Formula IIIa, IIIb, IIIc, or IIId:

4. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 2 is H, or C 1-4 alkyl.

5. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 3a is H.

6. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein R 3b is C 1-4 alkyl.

7. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein Cy is phenyl.

8. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein the subscript n is 0.

9. A compound of pharmaceutically acceptable salt thereof according to claim 1 , wherein the subscript n is 1 or 2.

10. A compound of pharmaceutically acceptable salt thereof according to claim 9 , wherein R 6 is halo, —CN, —NO 2 , C 1-4 alkyl optionally substituted with one or more halo, or C 1-4 alkoxy optionally substituted with one or more halo.

11. A compound of pharmaceutically acceptable salt thereof according to claim 9 , wherein R 6 is F, Cl, —CH 3 , or —OCH 3 .

12. A compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is:

(S)-5-[(3-oxo-3-((4S)-phenylpiperidin-1-yl)propyl])imidazolidine-2,4-dione,

5-[3-oxo-3-(4-phenyl-1-piperidyl)propyl]imidazolidine-2,4-dione,

5-(3-oxo-3-(4-phenylpiperidin-1-yl)propyl)-5-phenylimidazolidine-2,4-dione,

5-methyl-5-(3-oxo-3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

5-isopropyl-5-(3-oxo-3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

5-(3-(4-(2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-cyclopropyl-5-(3-oxo-3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

5-methyl-5-(3-oxo-3-(4-p-tolylpiperidin-1-yl) propyl)imidazolidine-2,4-dione,

5-(3-(4-(3,5-dichlorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(4-fluorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3-chlorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(4-chlorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3-fluorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(2-fluorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-methyl-5-(3-oxo-3-(4-m-tolylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

5-(3-oxo-3-(4-phenylpiperidin-1-yl)propyl)-5-(pyridin-3-yl)imidazolidine-2,4-dione,

5-cyclopropyl-5-(3-(4-(3,5-dichlorophenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(3-chlorophenyl)piperidin-1-yl)-3-oxopropyl)-5-cyclopropylimidazolidine-2,4-dione,

5-cyclopropyl-5-(3-(4-(3-fluorophenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-cyclopropyl-52-methyl-3-oxo-3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-3,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-3,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-methyl-5-((S)-2-methyl-3-oxo-3-(4-phenylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chlorophenyl)piperidin-1-yl)-2-methyl-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3,5-dichlorophenyl)piperidin-1-yl)-2-methyl-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(4-fluorophenyl)piperidin-1-yl)-2-methyl-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-methyl-5-(2-methyl-3-oxo-3-(4-m-tolylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

5-(3-(4-(3-fluorophenyl)piperidin-1-yl)-2-methyl-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3-chlorophenyl)piperidin-1-yl)-2-methyl-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-3-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-5-methoxy-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(3,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(2,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-3-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(4-chloro-5-methoxy-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(2,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(5-chloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(5-chloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(3,4-difluoro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3,4-difluoro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-3-fluoro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-3-fluoro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(3,5-dichloro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(3,5-dichloro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3-fluoro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-3-fluorophenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(4-fluoro-3-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(3,4-difluorophenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-3-fluorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(4-fluoro-3-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3,4-difluorophenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-methyl-5-(3-oxo-3-(4-o-tolylpiperidin-1-yl) propyl)imidazolidine-2,4-dione,

(R)-5-(3-oxo-3-(4-o-tolylpiperidin-1-yl)propyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4,5-dichloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4,5-dichloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(4-chloro-5-fluoro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4-chloro-5-fluoro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(3,5-dichloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(3-chloro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(3-chloro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(3,4-dichloro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(3,4-dichloro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(R)-5-(3-(4-(3,5-dichloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(4,5-dichloro-2-methylphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(4-fluoro-3,5-dimethoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-(3-(4-(3-chloro-4-fluoro-5-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

(R)-5-(3-(4-(3-chloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

5-(3-(4-(3-chloro-2-methoxyphenyl)piperidin-1-yl)-3-oxopropyl)-5-methylimidazolidine-2,4-dione,

5-cyclopropyl-5-(3-((3R,4R)-4-(3,4-difluorophenyl)-3-methylpiperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(S)-5-cyclopropyl-5-(3-((3R,4S)-4-(3,4-difluorophenyl)-3-methylpiperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(S)-5-cyclopropyl-5-(3-((3R,4R)-4-(3,4-difluorophenyl)-3-methylpiperidin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-2-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3-chloro-4-fluoro-5-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-fluoro-3,5-dimethoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-fluoro-3,5-dimethoxy-phenyl)-1-piperidyl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-fluoro-5-methoxy-2-methyl-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(3-chloro-2-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethoxy-5-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethoxy-5-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-2-methoxy-5-methyl-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-[4-chloro-3-(dimethylamino)-5-methoxy-phenyl]-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-[4-chloro-3-(dimethylamino)-5-methoxy-phenyl]-1-piperidyl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(4,5-dichloro-2-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-(6-methyl-2-pyridyl)imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3,5-dimethyl-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-[4-chloro-3-(trifluoromethyl)phenyl]-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-methyl-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4,5-dichloro-2-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3[4-(4-chloro-2-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-methoxy-5-methyl-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[(3R,4R)-4-(3,4-difluorophenyl)-3-methyl-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-5-fluoro-2-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(5-chloro-4-fluoro-2-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-ethyl-5-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethyl-5-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-ethyl-5-methoxy-phenyl)-1-piperidyl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(5-chloro-4-fluoro-2-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-2-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl) imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-5-fluoro-2-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-5-fluoro-2-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(5-chloro-4-fluoro-2-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-[5-(2-fluorophenyl)-2-thienyl]-1-piperidyl]-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-methoxy-5-methyl-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-methoxy-5-methyl-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione,

(5R)-5-[3-[4-(4-chloro-3-methoxy-5-methyl-phenyl)-1-piperidyl]-3-oxo-propyl]imidazolidine-2,4-dione,

5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione, or

5-[3-[4-(4-chloro-3-fluoro-5-methoxy-phenyl)-1-piperidyl]-2-methyl-3-oxo-propyl]-5-(methoxymethyl)imidazolidine-2,4-dione.

13. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 1 , and a pharmaceutically acceptable carrier.

14. A method for treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the compound or a pharmaceutically acceptable salt thereof of claim 1 , to said human.

15. A method for treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis in a human comprising administering an effective amount of the pharmaceutical composition according to claim 13 to the human.