NIR long lifetime indicator molecule
The invention relates to a porphyrin time domain indicator. The indicator may be used for detection of a particular analyte in vivo or in vitro. The indicator may be used for detection of glucose in vivo or in vitro.
1. A compound having the following structure:
wherein M is a metal which forms a chelated luminescent complex with tetraphenyl porphyrin ligand base structure or derivatives thereof;
each R1 is independently a linker group, a polymerizable group, or H;
each R2 independently comprises a phenyl, napthyl, anthryl, wherein at least one R2 further comprises a recognition element capable of detecting an analyte, wherein the recognition element is a boronate or derivative thereof.
2. The compound of claim 1 , wherein M is selected from the group consisting of: Pt, Pd, Al, Ru, Os, Ir, Al, Cu, Ag, Pb, Au, Eu, Tb, Rh, and Ni.
3. The compound of claim 1 , wherein at least one R1 comprises:
4. The compound of claim 1 wherein R1 is a linker group or H.
5. The compound of claim 1 wherein R1 is selected from the group consisting of: vinyl, acrylate, methacrylate, amides, polyethylene glycols, methacrylamides, carboxy, amine, sulfhydryl, and sulfonate.
6. The compound of claim 1 , wherein R1 is selected from the group consisting of: vinyl, acrylate, methacrylate, amides, polyethylene glycols, and methacrylamides.
7. The compound of claim 1 , wherein a polymeric backbone structure is covalently bonded to at least one R1.
8. The compound of claim 7 , wherein the polymeric backbone structure is a polymer, a copolymer, a hydrogel, or a derivative thereof.
9. The compound of claim 1 , wherein the at least one R2 further comprising a recognition element is selected from the group consisting of boronate coupled into a phenyl, napthyl, anthryl; a bis-boronate coupled into a phenyl, napthyl, anthryl; mono boronates of phenyl boronate, napthyl boronate, anthryl boronate; and bis-boronate derivations of phenyl, napthyl, or anthryl groups.
10. The compound of claim 1 , wherein each R2 further comprising a recognition element is independently selected from the group consisting of:
11. The compound of claim 1 , wherein the analyte is glucose.
12. The compound of claim 1 wherein two R2s further comprise a recognition element.
13. The compound of claim 1 wherein three R2s further comprise a recognition element.
14. The compound of claim 1 wherein four R2s further comprise a recognition element.
15. The compound of claim 1 wherein at least one R2 does not comprise a recognition element.
16. The compound of claim 15 wherein the at least one R2 not comprising a recognition element is napthyl.