Topical preparation for skin tissue protection and reparation

1. A complex preparation for skin protection and reparation, comprising the following ingredients:

(1) polyethylene glycol;

(2) water; and

(3) flavonoid compound;

wherein, the polyethylene glycol is:

a mixture composed of equal mass of a single-component polyethylene glycol having a molecular weight of 200-400, a single-component polyethylene glycol having a molecular weight of 2000-5000, and a single-component polyethylene glycol having a molecular weight of 6000-10,000.

2. The complex preparation of claim 1 , further comprising the following ingredients:

(4) soluble salt; and/or

(5) allantoin.

3. The complex preparation of claim 1 , wherein

the flavonoid compound is one, two or three selected from the group consisting of naringenin, liquiritigenin, hesperidin, quercetin, kaempferol, genistein, daidzein, luteolin, and apigenin;

the salt is one or more selected from the group consisting of sodium salts, potassium salts, and zinc salts.

4. The complex preparation of claim 1 , wherein, in the complex preparation, the mass ratio of the polyethylene glycol, the water, and the flavonoid compound is 50-80 to 20-30 to 2-10.

5. A preparation method of a complex preparation for skin protection and reparation of claim 1 , comprising the steps of:

step (1) heating the polyethylene glycol to 55° C.-90° C. to obtain a polyethylene glycol solution;

step (2) dissolving the flavonoid compound in the polyethylene glycol solution; and

step (3) adding water to the polyethylene glycol solution to be a mixed solution, and after mixing the mixed solution uniformly, cooling the mixed solution to normal temperature to be a solution system.

6. The preparation method of claim 5 , further comprising:

step (4) using a pH buffer to adjust the pH of the solution system to 6.0-8.0; wherein, the pH buffer is sodium citrate buffer, sodium bicarbonate buffer or PBS buffer.

7. A product for skin protection and reparation obtained by using the complex preparation of claim 1 , wherein

the product is a health care product/a cosmetic product/a medicine;

the product is prepared with the complex preparation for skin protection and reparation and adjuvants, excipients, flavoring agents or combinations of the adjuvants, excipients, and flavoring agents; and

the medicine is:

(1) a medicine for preventing or treating radiodermatitis; or

(2) a medicine for treating and preventing skin injury caused by radiation therapy.

8. A preparation method of a complex preparation for skin protection and reparation of claim 2 , comprising the steps of:

step (1) heating the polyethylene glycol to 55° C.-90° C. to obtain a polyethylene glycol solution;

step (2) dissolving the flavonoid compound in the polyethylene glycol solution; and

step (3) first dissolving the salt/allantoin in the water to obtain a salt/allantoin solution, then adding the salt/allantoin solution to the polyethylene glycol to obtain a mixed solution, and after mixing the mixed solution uniformly, cooling the mixed solution to normal temperature to be a solution system.

9. The preparation method of claim 8 , further comprising:

step (4) using a pH buffer to adjust the pH of the solution system to 6.0-8.0; wherein, the pH buffer is sodium citrate buffer, sodium bicarbonate buffer or PBS buffer.

10. The product of claim 7 , wherein, the complex preparation further comprises the following ingredients:

(4) soluble salt; and/or

(5) allantoin.