Multifunctional inhibitors of MEK/PI3K and mTOR/MEK/PI3K biological pathways and therapeutic methods using the same
View Patent ↗Multifunctional inhibitors of mTOR, MEK, and PI3K and compositions containing the same are disclosed. Methods of using the multifunctional inhibitors in the treatment of diseases and conditions wherein inhibition of one or more of mTOR, MEK, and PI3K provides a benefit, like cancers, also are disclosed.
1. A compound having a structure:
or a pharmaceutically acceptable salt thereof.
2. A compound having a structure
or a pharmaceutically acceptable salt thereof.
3. A compound selected from the group consisting of
4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or vehicle.
5. A method of treating a disease or condition wherein inhibition of at least one of mTOR, MEK, and PI3K provides a benefit comprising administering a therapeutically effective amount of a compound of claim 1 to an individual in need thereof.
6. The method of claim 5 wherein the disease or condition is a cancer.
7. The compound of claim 3 having a structure
8. The compound of claim 3 having a structure